Results 31 to 40 of about 129,481 (261)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Awareness with Recall During General Anesthesia: A Cross-Sectional Study

Pakistan Journal of Medicine and Dentistry
Background: Accidental awareness and recall a well-known complication of anesthesia and sedation despite advancements in monitoring, drugs, and techniques.
Maheen Najeeb, Tayab, Shahrukh, Mukhtair Ahmad, Salman Mailk, Muhammad Tayyab, Muhammad Taimur Asad, Subhan Ali   +7 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Remote real-time supervision of prehospital point-of-care ultrasound: a feasibility study

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2022
Background Although prehospital point-of-care ultrasound (POCUS) is gaining in importance, its rapid interpretation remains challenging in prehospital emergency situations.
Martina Hermann, Christina Hafner, Vincenz Scharner, Mojca Hribersek, Mathias Maleczek, Andreas Schmid, Eva Schaden, Harald Willschke, Thomas Hamp   +8 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

THE EFFECTS OF GENERAL AND EPIDURAL ANAESTHESIA ON THE NUMBER OF LEUCOCYTES AND THE DISTRIBUTION OF LEUCOCYTES SUBGROUPS

Eurasian Journal of Medicine, 2019
General and regional anaesthesia, along with surgery compromise the immun system and affect the number and sugroup distribution of leucocytes. In this study we aimed to compere the number of leucocytes and subgroups in patients who received general ...
Nazım Doğan, Hüsnü Kürşad, Hacı Ahmet Alıcı, Mehmet Cesur   +3 more
doaj  

Thrombin Generation and Platelet Function in ICU Patients Undergoing CVVHD Using Regional Citrate Anticoagulation

Frontiers in Medicine, 2021
Background: To investigate pro- and anticoagulant alterations in uremic critically ill patients prior to and during continuous renal replacement therapy.
Marion Wiegele, Lukas Infanger, Conrad Lacom, Stefan Koch, Andreas Baierl, Eva Schaden   +5 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

The Role of Infiltrative Local Anaesthesia in Thyroidectomy

The Annals of African Surgery, 2013
Background: General anaesthesia is the anaesthetic agent of choice during thyroidectomy, however, recent reports there is a role for local anaesthesia. This study reports on the experience of thyroidectomy performed under infiltrative local anaesthesia ...
Ojuka KD, Saidi H, Rere EC
doaj  

A snap-shot survey of spinal anaesthesia for caesarean section: The Nigeria experience

Journal of Clinical Sciences, 2017
Background and Objective: In the last several decades, there has been a shift from general anaesthesia to regional anaesthesia for caesarean section worldwide.
Charles Imarengiaye, Felicia Asudo, Allen Akinmola, Bode Lawal   +3 more
doaj   +1 more source