Results 51 to 60 of about 494,967 (291)

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Major animal health problems of market oriented livestock development in Alamata woreda [PDF]

, 2010
An attempt was made to study major health problems of livestock in Alamata Woreda, northern Ethiopia, from December 2006 to April 2007. Questionnaire survey was carried out on 100 livestock owners to collect information on the livestock production system
Tekle, Y.
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Cardiorehabilitation аnd quality of life of patients with cardiovascular diseases

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2016
Submitted data detected miscellaneous changes of life quality indicators of patients with cardiovascular pathology who took part in cardiorehabilitation programmes of various duration.
T. A. Evdokimova, A. E. Kutuzova, A. A. Potapchuk, O. E. Malneva   +3 more
doaj   +1 more source

ACUTE ABDOMEN in PREGNANCY: AETIOLOGY & ‎OUTCOME in BASRAH [PDF]

Basrah Journal of Surgery, 2004
This is a prospective study conducted in all major hospitals in Basrah (Basrah Maternity & Child ‎Hospital, Basrah Teaching hospital and Basra General hospital) to prove that ‘acute abdomen in ‎pregnancy’ is common and that the effect of delayed ...
Fouad Hamad Al-Dahhan, Ehab A. Hassan
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Computational methods for detecting cancer hotspots

Computational and Structural Biotechnology Journal, 2020
Cancer mutations that are recurrently observed among patients are known as hotspots. Hotspots are highly relevant because they are, presumably, likely functional. Known hotspots in BRAF, PIK3CA, TP53, KRAS, IDH1 support this idea.
Emmanuel Martinez-Ledesma, PhD, David Flores, Victor Trevino   +2 more
doaj   +1 more source

A proposal for (0,2) mirrors of toric varieties

, 2017
In this paper we propose (0,2) mirrors for general Fano toric varieties with special tangent bundle deformations, corresponding to subsets of toric deformations.
Gu, W., Sharpe, E.
core   +1 more source