Results 81 to 90 of about 3,936,944 (293)
Happy 100th, structural biology [PDF]
Structural DynamicsAbout 100 years ago, the field of structural biology was born, led by James B. Sumner who recognized that enzymes were molecules with specific functions.
George N. Phillips, Jr. +1 more
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Exposure to endosulfan can cause long term effects on general biology, including the reproductive system of mice. [PDF]
Front Genet, 2022 Sharma A +5 more
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Global Optimization, Local Adaptation, and the Role of Growth in Distribution Networks
, 2016 Highly-optimized complex transport networks serve crucial functions in many man-made and natural systems such as power grids and plant or animal vasculature.
Katifori, Eleni, Ronellenfitsch, Henrik
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Implementation of a Flipped Active-Learning Approach in a Community College General Biology Course Improves Student Performance in Subsequent Biology Courses and Increases Graduation Rate. [PDF]
CBE Life Sci Educ, 2021 Riedl A, Yeung F, Burke T.
europepmc +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Africa: the FBA connection [PDF]
, 1986 Since its inception in the 1930's the Freshwater Biological Association at Windermere, England has been involved in research on African lakes and rivers.
Fryer, G., Talling, J.F.
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Systems Biology — the Broader Perspective
Cells, 2013 Systems biology has two general aims: a narrow one, which is to discover how complex networks of proteins work, and a broader one, which is to integrate the molecular and network data with the generation and function of organism phenotypes.
Jonathan Bard
doaj +1 more source