Results 61 to 70 of about 284,421 (254)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Incident Response: Protecting Individual Rights Under the General Data Protection Regulation
SCRIPTed: A Journal of Law, Technology & Society, 2016 Identifying and fixing problems with the security of computers and networks is essential to protect the data they contain and the privacy of their users.
Andrew Cormack
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
General Data Protection Regulation – results of a pilot study [PDF]
European Journal of Service Management, 2018 The article focuses on the social aspects of the GDPR implementation. Paper presents the results of a study conducted in 2018, after the introduction of legislative changes. The study was exploratory and its aim was to find out how administrative employees evaluated and feels about GDPR. The survey was conducted as an online survey questionnaire.
Czaplewski, Maciej +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MANAGING INNOVATIVE COMPANY’S CAPITAL: THE CASE OF PERSONAL DATA TRANSFER
Zbornik Pravnog Fakulteta Sveučilišta u Rijeci, 2018 protection. The only case in which this issue could become more debatable is if personal data crosses EU borders. The transfer of personal data to third countries proved its disputed status when the CJEU invalidated the Safe Harbour Agreement, one of the
Danijela Vrbljanac
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Integrating Technical and Legal Concepts of Privacy
IEEE Access, 2018 We provide an overview of legal and technical concepts of privacy protection. Data protection guarantees exist in European Union at a primary law level since 2009, when the Lisbon Treaty has become effective.
Ana Sokolovska, Ljupco Kocarev
doaj +1 more source