Results 81 to 90 of about 38,870,795 (288)
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Position Paper on the General Data Protection Regulation
, 2015 BBMRI-ERIC acknowledges and embraces the dynamic potential of the General Data Protection Regulation for the ERA. At the same time, wrongly aimed provisions could seriously hamper pan- European research as well.
Michaela Th. Mayrhofer +7 more
core +1 more source
Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis
FEBS Open Bio, EarlyView.Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto +14 more
wiley +1 more source
Integrating Technical and Legal Concepts of Privacy
IEEE Access, 2018 We provide an overview of legal and technical concepts of privacy protection. Data protection guarantees exist in European Union at a primary law level since 2009, when the Lisbon Treaty has become effective.
Ana Sokolovska, Ljupco Kocarev
doaj +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Thoughts on General Data Protection Regulation and Online Human Surveillance [PDF]
, 2020 The European Union General Data Protection Regulation (GDPR) has introduced online privacy and transparency for consumers as well as legal considerations that companies must ...
Kshetri, Nir B. +1 more
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FEBS Open Bio, EarlyView.During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa +4 more
wiley +1 more source
Law Research Review QuarterlyAdvances in digital technology increase the risk of misuse of children’s personal data, thereby placing children as a vulnerable group in the digital space.
Yessi Ainurohwati, Andry Setiawan
doaj +1 more source
Frequently asked questions / Data Protection Commissioner
, 2008 Office of the Data Protection Commissioner / [200?
Office of the Data Protection Commissioner
core
FEBS Open Bio, EarlyView.Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page +4 more
wiley +1 more source