Results 61 to 70 of about 37,194,254 (247)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Biomedical research - achieving transparency under the General Data Protection Regulation [PDF]
, 2018 A new European regulation on data protection is currently keeping organisations across Europe busy in adapting their procedures, policies and documentation to meet the new requirements.
BECKER, Regina
core +1 more source
Risk assessment of data protection in the maritime industry using system-theoretic process analysis
Results in EngineeringThe maritime industry is one of the most hazardous industries in the world. Risk assessment is applied in various contexts within this industry to prevent hazardous situations affecting systems and humans. Risk assessment in the maritime industry relates
Sutthipong Yungratog +3 more
doaj +1 more source
Data protection guidelines on research in the health sector [PDF]
, 2007 Office of the Data Protection ...
Office of the Data Protection Commissioner
core
Data Protection by Design and by Default à la European General Data Protection Regulation
, 2016 Part 1: Keynote and Invited PapersInternational audienceThe European data protection reform has resulted in a new regulation that will be effective from May 2018.
Hansen, Marit, Marit Hansen
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Data protection and consumer protection: The empowerment of the citizen-consumer
, 2023 There has been an ongoing discussion of the overlaps and complementary functions of privacy and data protection and consumer protection law. However, although much of this has remained at a rather abstract level, recent legislative changes are ...
Clifford, Damian
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Personal information management systems: a user-centric privacy utopia?
Internet Policy Review, 2020 Personal information management systems (PIMS) aka personal data stores (PDSs) represent an emerging class of technology that seeks to empower individuals regarding their data.
Heleen Janssen +2 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source