Results 101 to 110 of about 7,269,794 (356)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

WAEC/NECO Senior School Certificate (SSC), General Certificate of Education Ordinary Level (GCE O'Level), or their equivalents with credits in five (5) subjects obtained at one sitting or six (6) credits at not more than two sittings.

, 2022
James Kelvin
openalex   +2 more sources

The pain of low status: the relationship between subjective socio-economic status and analgesic prescriptions in a Scottish community sample [PDF]

, 2016
There is a strong positive relationship between objective measures of socioeconomic status (OSS) and general health. However, there is an increasing interest in the relationship between health and subjective socioeconomic status (SSS), which describes ...
Fabio Sani, Fuentes M., Joint Formulary Committee, Juliet Ruth Helen Wakefield, Melzack R., Michael Norbury, Pat Dugard, Peterson C., Scottish Government, Scottish Intercollegiate Guidelines Network, Vishnu Madhok   +10 more
core   +3 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Sustainability: Teaching an Interdisciplinary Threshold Concept through Traditional Lecture and Active Learning

Canadian Journal for the Scholarship of Teaching and Learning, 2015
One of the difficulties in teaching global sustainability in the introductory political science classes is the different emphases placed on this concept and the absence of the consensus on where the overall balance between environmental protection ...
Ekaterina M. Levintova, Daniel W. Mueller   +1 more
doaj  

Das Problem der Allgemeinbildung geschichtlich betrachtet

Paedagogia Christiana, 2014
Problem kształcenia ogólnego z perspektywy historycznej(Streszczenie)Przeobrażanie się terminu „encyklopedia“ stanowi odzwierciedlenie historycznego postępu wiedzy i zmian w edukacji.
Gunter Scholtz
doaj   +1 more source

The demographic challenge facing Scottish higher education institutions : a computable general equilibrium analysis [PDF]

, 2009
Higher Education Institutions (HEIs) are generally regarded as important actors in regional economic development. A large literature exists on their demand side impacts as employers and as purchasers of intermediate inputs and, more recently, work has ...
Hermannsson, Kristinn, Lisenkova, Katerina, McGregor, Peter, Swales, John K.   +3 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Development and validation of an instrument to collect students’ perceptions of upper secondary education programmes

Educar
This article details the design and validation of the Students’ Perceptions of Upper Secondary Education Programmes (SPUSEP) instrument, developed to explore Portuguese students’ experiences of transitioning into upper secondary education.
Ana Cristina Torres
doaj   +1 more source