Results 171 to 180 of about 75,069 (304)

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

open access: yesAdvanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang   +32 more
wiley   +1 more source

Aiken Ballot Audit Report - 2014 General Election

open access: yes, 2014
This audit report by the South Carolina State Election Commission for the 2014 General Election in Aiken County provides reports generated by the iVotronic voting machines and Unity election ...
South Carolina State Election Commission
core  

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

open access: yesAdvanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang   +9 more
wiley   +1 more source

Greenwood Ballot Audit Report - 2014 General Election

open access: yes, 2014
This audit report by the South Carolina State Election Commission for the 2014 General Election in Greenwood County provides reports generated by the iVotronic voting machines and Unity election ...
South Carolina State Election Commission
core  

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

open access: yesAdvanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska   +14 more
wiley   +1 more source

Oconee Ballot Audit Report - 2014 General Election

open access: yes, 2014
This audit report by the South Carolina State Election Commission for the 2014 General Election in Oconee County provides reports generated by the iVotronic voting machines and Unity election ...
South Carolina State Election Commission
core  

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

open access: yesAdvanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller   +6 more
wiley   +1 more source

Fairfield Ballot Audit Report - 2014 General Election

open access: yes, 2014
This audit report by the South Carolina State Election Commission for the 2014 General Election in Fairfield County provides reports generated by the iVotronic voting machines and Unity election ...
South Carolina State Election Commission
core  

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