Results 51 to 60 of about 1,618,039 (306)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Hoard or Exploit? Intergenerational Allocation of Exhaustible Natural Resources

Energies, 2020
In this paper, a “general equilibrium” (GE) model was developed for the allocation of exhaustible natural resources to examine the impact of different extraction scenarios on intergenerational economic welfare. A stylized GE model was applied to Israel’s
Hala Abu-Kalla, Ruslana Rachel Palatnik, Ofira Ayalon, Mordechai Shechter   +3 more
doaj   +1 more source

The von Neumann Model and the Early Models of General Equilibrium [PDF]

, 2003
The paper reconstructs the von Neumann model, comments on its salient features and critically reviews some of its generalisations. The issues related to thetreatment of consumption, decomposability and uniqueness of the rate of growth and interest will ...
Zalai, Ernő
core   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

MODEL OF PARTIAL ECONOMIC BALANCE OF THE AUTOMOBILE PRODUCTS OF UKRAINE

Фінансово-кредитна діяльність: проблеми теорії та практики, 2020
. The purpose of the article is to substantiate the concept and to build a model of partial economic equilibrium of the automotive products market by market segments (cars, trucks and buses) on the basis of the Walras and Errow-Debre equilibrium models ...
M. R. Tymoshchuk, V. O. Terletska, R. V. Feshchur, S. V. Shyshkovskyi, O.V. Kopytko   +4 more
doaj   +1 more source

Validating Dynamic General Equilibrium Model Forecasts [PDF]

The maintained hypotheses embodied in structural general equilibrium models calibrated to data have tended to make economists and policy makers insecure regarding their empirical foundation.
Li, NaiChia, Roe, Terry L.
core   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

A Two-Country Discontinuous General Equilibrium Model [PDF]

The aim of this paper is to develop a continuous time general equilibrium model for a two country Lucas type economy. The model assumes that the output in the two countries follows a jump-diffusion stochastic process. We obtain the results concerning the
Ciprian Necula
core  

A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems

International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam, Anthony Siming Chen, Guido Herrmann   +2 more
wiley   +1 more source

Multiregional Models of General Equilibrium: Framework and Applications

Управленческое консультирование, 2018
Computable general equilibrium (CGE) modelshelp to assess various aspects of economic policy. Multiregional CGE framework allowsanalyzing challenging issues of trade, tax and environmental policies, such as entering international trade organizations ...
K. V. Nesterova
doaj   +1 more source