Results 41 to 50 of about 15,836,527 (311)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
The Firm and the Plant in General Equilibrium Theory [PDF]
, 1989 The general equilibrium formulations are developed for two important economic environments. The first environment is the Lucas managerial span-of-control theory of the firm. It is shown that, in the spirit of McKenzie, the aggregate production set can be characterized by a convex cone.
Andreas Hornstein, Edward C. Prescott
openaire +2 more sources
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
About manifolds and determinacy in general equilibrium theory.
Estudios de Economía, 2003 En este artículo se demuestra que el conjunto de equilibrio social de una economía de intercambio, con espacio de consumo contenido en un espacio de Banach, es una variedad en dicho Banach, cuya caracterización no depende del número de bienes.
Elvio Accinelli
doaj
Notes on Michio Morishima's Understanding of Marxian Economics
World Review of Political Economy, 2019 Michio Morishima's recapitulation and study of Marxian economics by means of mathematical methods focus primarily on the typical themes such as the labor theory of value, the theory of exploitation, the transformation problem, the
Xian Zhang
doaj +1 more source
A minimal cellulosome‐like system in Cellulosilyticum lentocellum
FEBS Open Bio, EarlyView.Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan +2 more
wiley +1 more source
Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1
FEBS Open Bio, EarlyView.The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn +2 more
wiley +1 more source
Asian Development Review, 1983 The family is a remarkable institution. And a complex one. Indeed, so complex that much of economic theory proceeds as if no such thing exists. In the standard theory of prices and equilibrium (the most elegant version of which is to be found in the ...
Amartya Sen
doaj +1 more source
Controller design for inverted pendulum stabilizing on equilibrium manifold based on vector field
Nihon Kikai Gakkai ronbunshu, 2020 In general, mechanical systems are stabilized on their equilibrium point. Equilibrium point is often not unique and they are continuously connected, which is an equilibrium manifold.
Masafumi OKADA, Yutaka OKAMOTO
doaj +1 more source