Results 41 to 50 of about 126,639 (310)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Green finance and urban carbon emission dual control: an empirical evidence from China

Frontiers in Environmental Science
The Chinese government has proposed shifting the regulation of energy consumption and intensity towards a dual control system of total carbon emissions and carbon emission intensity gradually, aiming to promote the continued role of green finance in ...
Tian Zhang, Yao Zhang, Yumin Zhang
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Intertemporal General Equilibrium and Monetary Theory [PDF]

, 2001
Theory is often at odds with the thinking and practice of monetary authorities. A confrontation of this situation is timely. General equilibrium theory serves to check the consistency of models and to bring out some of their properties. Surprisingly, an enquiry into monetary theory from the perspective of general equilibrium leads to conclusions that ...
DREZE, Jacques H., POLEMARCHAKIS, Heracles M.   +1 more
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

About manifolds and determinacy in general equilibrium theory.

Estudios de Economía, 2003
En este artículo se demuestra que el conjunto de equilibrio social de una economía de intercambio, con espacio de consumo contenido en un espacio de Banach, es una variedad en dicho Banach, cuya caracterización no depende del número de bienes.
Elvio Accinelli
doaj  

Notes on Michio Morishima's Understanding of Marxian Economics

World Review of Political Economy, 2019
Michio Morishima's recapitulation and study of Marxian economics by means of mathematical methods focus primarily on the typical themes such as the labor theory of value, the theory of exploitation, the transformation problem, the
Xian Zhang
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Controller design for inverted pendulum stabilizing on equilibrium manifold based on vector field

Nihon Kikai Gakkai ronbunshu, 2020
In general, mechanical systems are stabilized on their equilibrium point. Equilibrium point is often not unique and they are continuously connected, which is an equilibrium manifold.
Masafumi OKADA, Yutaka OKAMOTO
doaj   +1 more source