Results 51 to 60 of about 13,688 (264)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

General fractional operators with fixed memory length: definitions and properties

Demonstratio Mathematica
This paper proposes the definitions of general fractional operators with fixed memory length in several function spaces. Firstly, some properties of the general fractional integral with fixed memory length, such as boundedness, continuity, semigroup ...
Wang Rong-Fu, Gu Chuan-Yun, Zeng Ni
doaj   +1 more source

Saigo fractional integral operators with incomplete R-functions kernel

Mathematics Open
Fractional calculus has emerged as a robust analytical framework with wide-ranging applications across mathematical analysis, including differential and integral equations, special functions, and series representations.
Priti Purohit, Ravi Gupta, Shyamsunder
doaj   +1 more source

Generalized Hermite-Hadamard type inequalities involving fractional integral operators

Journal of Inequalities and Applications, 2017
In this article, a new general integral identity involving generalized fractional integral operators is established. With the help of this identity new Hermite-Hadamard type inequalities are obtained for functions whose absolute values of derivatives are
Erhan Set, Muhammed Aslam Noor, Muhammed Uzair Awan, Abdurrahman Gözpinar   +3 more
doaj   +1 more source

On the generalized fractional integrals of the generalized Mittag-Leffler function [PDF]

SpringerPlus, 2014
In this paper, we employ the generalized fractional calculus operators on the generalized Mittag-Leffler function. Some results associated with generalized Wright function are obtained. Recent results of Chaurasia and Pandey are obtained as special cases.33C45, 47G20, 26A33.
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

General Fractional Dynamics

Mathematics, 2021
General fractional dynamics (GFDynamics) can be viewed as an interdisciplinary science, in which the nonlocal properties of linear and nonlinear dynamical systems are studied by using general fractional calculus, equations with general fractional ...
Vasily E. Tarasov
doaj   +1 more source

On a Generalized Laguerre Operational Matrix of Fractional Integration [PDF]

Mathematical Problems in Engineering, 2013
A new operational matrix of fractional integration of arbitrary order for generalized Laguerre polynomials is derived. The fractional integration is described in the Riemann-Liouville sense. This operational matrix is applied together with generalized Laguerre tau method for solving general linear multiterm fractional differential equations (FDEs). The
Bhrawy, A. H., Baleanu, Dumitru, Assas, L. M., Machado, J.A.Tenreiro   +3 more
openaire   +3 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source