Results 81 to 90 of about 183,387 (282)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
, 1995 Talk presented by J.L. Petersen at the 29th Symposium Ahrenshop, Buckow August 29-September 2, 1995. A presentation is given of the free field realization relevant to SL(2) WZW theories with a Hilbert space based on admissible representations.
Aharony +43 more
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
The solution of certain triple q-integral equations in fractional q-calculus approach
Arab Journal of Mathematical Sciences, 2019 In this paper, we consider a certain system of triple q-integral equations, where the kernel is the third Jackson q-Bessel functions. We give two solutions by using the fractional q-calculus approach. We study also the system with general kernel.
M.A. AL-Towailb
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The two forms of fractional relaxation of distributed order
, 2006 The first-order differential equation of exponential relaxation can be generalized by using either the fractional derivative in the Riemann-Liouville (R-L) sense and in the Caputo (C) sense, both of a single order less than 1.
Gorenflo, Rudolf +3 more
core +3 more sources
A new Generalized fractional derivative and integral
, 2017 In this article, we introduce a new general definition of fractional derivative and fractional integral, which depends on an unknown kernel. By using these definitions, we obtain the basic properties of fractional integral and fractional derivative such as Product Rule, Quotient Rule, Chain Rule, Roll's Theorem and Mean Value Theorem.
AKKURT, Abdullah +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Analysis of Implicit Uncertain Systems. Part I: Theoretical Framework [PDF]
, 1994 This paper introduces a general and powerful framework for the analysis of uncertain systems, encompassing linear fractional transformations, the behavioral approach for system theory and the integral quadratic constraint formulation. In this approach, a
Doyle, John, Paganini, Fernando
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source