Results 81 to 90 of about 13,688 (264)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

On the boundedness of a generalized fractional integral on generalized Morrey spaces

Tamkang Journal of Mathematics, 2002
In this paper we extend Nakai's result on the boundedness of a generalized fractional integral operator from a generalized Morrey space to another generalized Morrey or Campanato space.
openaire   +4 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Fractional Transforms in Optical Information Processing

EURASIP Journal on Advances in Signal Processing, 2005
We review the progress achieved in optical information processing during the last decade by applying fractional linear integral transforms. The fractional Fourier transform and its applications for phase retrieval, beam characterization, space-variant ...
Maria Luisa Calvo, Martin J. Bastiaans, Tatiana Alieva   +2 more
doaj   +1 more source

Extensions of different type parameterized inequalities for generalized (m,h) $(m,h)$-preinvex mappings via k-fractional integrals

Journal of Inequalities and Applications, 2018
The authors discover a general k-fractional integral identity with multi-parameters for twice differentiable functions. By using this integral equation, the authors derive some new bounds on Hermite–Hadamard’s and Simpson’s inequalities for generalized ...
Yao Zhang, Ting-Song Du, Hao Wang, Yan-Jun Shen, Artion Kashuri   +4 more
doaj   +1 more source

Some generalized integral inequalities via fractional integrals

, 2020
Summary: The main goal of this paper is to introduce a new integral definition concerned with the fractional calculus. Then we establish generalized Hermite-Hadamard type integral inequalities for convex functions using the proposed fractional integrals. The results presented provide extensions of those given in earlier works.
Sarıkaya, Mehmet Zeki, Budak, Hüseyin, Usta, Fuat   +2 more
openaire   +3 more sources

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

An introduction to the generalized fractional integration

Boletim da Sociedade Paranaense de Matemática, 2012
Summary: The purpose of the present paper is to investigate the generalized fractional integration of the generalized \(M\)-series. Some results derived by \textit{R. K. Saxena} and \textit{M. Saigo} [Fract. Calc. Appl. Anal. 8, No. 2, 141--154 (2005; Zbl 1144.26010)], \textit{St. G. Samko} et al.
openaire   +2 more sources

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source