Results 111 to 120 of about 10,127,947 (331)

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

International factor mobility, informal interest rate and capital market imperfection: a general equilibrium analysis [PDF]

open access: yes
This paper makes a pioneering attempt to provide a theory of determination of interest rate in the informal credit market in a small open economy in terms of a three-sector general equilibrium model. There are two informal sectors which obtain production
Chaudhuri, Sarbajit   +1 more
core   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

General Public Interest: between Electoral Rhetoric and Administrative Actions

open access: yesJournal of Danubian Studies and Research, 2012
Traditionally, public administration is considered to be the operative side of government. Itis supposed to include all the activities involved in carrying out the policies of the elected officialsand some activities associated with the development of ...
Valentina Cornea
doaj  

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

Governing growth in organic farming: The evolving capacities of organic groups in the United Kingdom and Denmark [PDF]

open access: yes, 2008
The question of the ‘policy capacity’ of interest groups is increasingly gaining prominence as a key variable in governing and transformative capacities. This raises the issue of whether group policy capacities can be developed. While group scholars have
Daugbjerg, Carsten, Halpin, Darren
core  

Serviciile publice. Considerații asupra legislației și practicii comunitare în domeniu, în contextul elaborării proiectului codului administrativ

open access: yesRevista Transilvană de Ştiinţe Administrative, 2011
The Romanian Administrative Code represents the main outcome of the project “A more coherent legislative framework for a more efficient public administration”, financed through the Operational Programme for the Development of the Administrative Capacity ...
Domnica FOCŞĂNEANU   +3 more
doaj  

General Interest Section

open access: yesJournal of the Royal Statistical Society Series C: Applied Statistics, 1991
Wojtek J. Krzanowski, Donald Preece
openaire   +2 more sources

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