Results 121 to 130 of about 15,812,427 (330)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Imaging SNAREs at work in ‘unroofed’ cells – approaches that may be of general interest for functional studies on membrane proteins [PDF]
, 2003 Thorsten Lang
openalex +1 more source
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Revista Transilvană de Ştiinţe Administrative, 2011 The Romanian Administrative Code represents the main outcome of the project “A more coherent legislative framework for a more efficient public administration”, financed through the Operational Programme for the Development of the Administrative Capacity ...
Domnica FOCŞĂNEANU +3 more
doaj
General practitioners with a special interest in dermatology – the dermatologist’s perspective [PDF]
, 2003 C.M. Lawrence
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Journal of the Royal Statistical Society Series C: Applied Statistics, 1991 Wojtek J. Krzanowski, Donald Preece
openaire +2 more sources
Policy instrument choice and non-coordinated monetary in interdependent economies [PDF]
Non-coordinated monetary policy is analysed in a stochastic two-country general equilibrium model. Non-coordinated equilibria are compared in two cases: one where policy is set in terms of state-contingent money supply rules and one where policy is set ...
Lombardo, Giovanni, Sutherland, Alan
core
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
The economic perspective of respiratory general practitioners with a special interest (GPwSIs): proceed with caution [PDF]
, 2003 David Kernick
openalex +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source