Results 141 to 150 of about 13,224,583 (303)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

EXPROPRIATION AS A WAY TO CEASE OR LIMIT THE PROPERTY RIGHTS

open access: yesPravo, 2009
In this paper, we look to the legal regulation of expropriation in Bosnia and Herzegovina, with particular emphasis on international acts to regulate property rights.
Marinko Džudović
doaj  

Trinity: Syncretizing Multi-/Long-tail/Long-term Interests All in One [PDF]

open access: yesarXiv
Interest modeling in recommender system has been a constant topic for improving user experience, and typical interest modeling tasks (e.g. multi-interest, long-tail interest and long-term interest) have been investigated in many existing works. However, most of them only consider one interest in isolation, while neglecting their interrelationships.
arxiv  

Evaluation of a general practitioner with special interest service for dermatology: randomised controlled trial [PDF]

open access: bronze, 2005
Chris Salisbury   +7 more
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Can One Embedding Fit All? A Multi-Interest Learning Paradigm Towards Improving User Interest Diversity Fairness [PDF]

open access: yesarXiv
Recommender systems (RSs) have gained widespread applications across various domains owing to the superior ability to capture users' interests. However, the complexity and nuanced nature of users' interests, which span a wide range of diversity, pose a significant challenge in delivering fair recommendations.
arxiv  

Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations

open access: yesFEBS Open Bio, EarlyView.
We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo   +2 more
wiley   +1 more source

Can accounting standardization serve the public interest?

open access: yesAudit Financiar, 2018
In line with his concerns to conceptualize the accounting principles and practices, the author develops the topic that falls under the above title, based on the premise that the facts and developments during the economic crisis show that accounting ...
doaj   +1 more source

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