Results 51 to 60 of about 3,690,653 (268)

Top5itis Revisited: Some Thoughts on the Notion of General Interest in Economics

open access: yesEnsayos Revista de Economía
Top5itis is a disease that currently affects the economics discipline. It refers to the obsession of the profession of academic economists with the so-called “top5” journals, also referred to as “top general-interest” journals.
Roberto Serrano
doaj   +1 more source

Intérêt commun ou intérêt général ? De l’enjeu d’une décision terminologique chez Rousseau

open access: yesAstérion, 2017
In this article, I offer a new interpretation for Rousseau’s surprisingly spare use of the phrase “general interest” in his works. My starting point is the very notion of interest in his political thought.
Théophile Pénigaud de Mourgues
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

open access: yesFEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Choice of Healer: An important area of interest for general practitioners

open access: yesSouth African Family Practice, 1985
No abstract available.
Emile Boonzaaier
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Butil bromuro de hioscina: ¿Una opción para el manejo de bradicardia intraoperatoria? [PDF]

open access: yesRevista Chilena de Anestesia, 2023
María J. Andrade   +3 more
doaj   +1 more source

Slovenian Complementary Health Insurance as a Service of General Economic Interest

open access: yesCentral European Public Administration Review, 2015
Slovenian legislation defines complementary health insurance as an activity of the public interest, which represents an inseparable and essential element of healthcare system and as such pursues objectives identical to those of compulsory health ...
Bruno Nikolić
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

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