Results 31 to 40 of about 874,139 (215)
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
GMS Zeitschrift für Medizinische Ausbildung, 2008 [english] Background: General medicine as an elective practical subject in the last year of basic medical education has recently been added to our medical school curriculum. Clerkships in general medicine have been widely defined around the world.
Lorenz, Gernot +2 more
doaj
Clinical Case ReportsKey Clinical Message Pyroglutamic acidosis (PGA) or 5‐Oxoprolinuria is an uncommon and often overlooked cause of high anion gap metabolic acidosis (HAGMA).
Aaron Yee Shuen See +2 more
doaj +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
International Journal of General Medicine, 2022 Takashi Watari,1– 3 Yasuhisa Nakano,4 Ashwin Gupta,2,3 Minami Kakehi,4 Ayuko Tokonami,4 Yasuharu Tokuda5 1General Medicine Center, Shimane University Hospital, Izumo, Shimane, Japan; 2Department of Medicine, University of Michigan Medical School, Ann ...
Watari T +5 more
doaj
Bad Medicine: Generation X [PDF]
British Journal of General Practice, 2019 I am part of Generation X. A title that makes us sound like sad wannabe mysterious nerd types with no imagination. We are the forgotten generation. Not the narcissist baby-boomers intent on a life of indulgent self discovery, nor the ever-angry and entitled ‘TAKE ME SERIOUSLY’ millennials, who will never be as special as the parents told them they were.
openaire +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
The use of a Swedish telephone medical advice service by the elderly – a population-based study
Scandinavian Journal of Primary Health Care, 2017 Objective: The present study aimed to describe contact made by the elderly to Sweden’s nationwide medical helpline, Healthcare Guide 1177 by Phone (HGP).
K. Dahlgren +5 more
doaj +1 more source