Results 41 to 50 of about 3,411,735 (299)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Internal Assessment of Isfahan General Medicine Curriculum Based on Basic standards of Ministry of Health and Medical Education: A Model for Evaluation and Analysis of Results [PDF]

مجله ایرانی آموزش در علوم پزشکی, 2011
Introduction: Necessity for promotion of education quality in course of medicine forced the educational authorities including those of Isfahan school of Medicine to take actions towards promotion of education using an accreditation evaluation model in ...
Mostafa Dehghani Poudeh, Behzad Shams, vahid Ashourioun, Atosa Esmaeilee, Ali Asilian, Parveneh Nasri, Marzieh Hosseini   +6 more
doaj  

Characteristics of outpatients with functional somatic syndromes at a university hospital's general medicine clinic

Journal of General and Family Medicine, 2022
Background The term medically unexplained symptoms (MUS) is unhelpful for both patients and physicians, and more acceptable illness categories are needed as substitutes for MUS.
Junji Nishiyama, Tetsuya Abe, Sumito Imaizumi, Akira Yamane, Mikihiko Fukunaga   +4 more
doaj   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Die Versorgungssituation von Patient:innen mit spastischer Bewegungsstörung in Deutschland: ein Vergleich (II)

Monitor Versorgungsforschung, 2022
Hintergrund: Unterschiedlichste Publikationen der jüngeren Vergangenheit beschäftigten sich mit der Versorgungsrealität von Patient:innen mit spastischen Bewegungsstörungen in Deutschland und offenbarten eine Versorgung, die nicht mit den aktualisierten ...
Lukas Völkel MSc, Prof. Dr. rer. pol. h.c. Herbert Rebscher, Prof. Dr. rer. soc. Dr. med. Reinhard P.T. Rychlik   +2 more
doaj   +1 more source

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, EarlyView.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Hands-on Clinical Clerkship at the Department of General Medicine in a University Hospital Improves Medical Students’ Self-Evaluation of Skills of Performing Physical Examinations and Informed Consent: A Questionnaire-Based Prospective Study

International Journal of General Medicine, 2022
Yoshinori Tokushima,1,2 Masaki Tago,1,2 Midori Tokushima,1,3 Shun Yamashita,1 Yuka Hirakawa,1 Hidetoshi Aihara,1 Naoko E Katsuki,1 Motoshi Fujiwara,1 Shu-ichi Yamashita1 1Department of General Medicine, Saga University Hospital, Saga, Japan; 2Community ...
Tokushima Y, Tago M, Tokushima M, Yamashita S, Hirakawa Y, Aihara H, Katsuki NE, Fujiwara M, Yamashita SI   +8 more
doaj  

The future of general medicine [PDF]

Clinical Medicine, 2014
It is a truth universally acknowledged that there is a problem with general medicine. Physicians have become increasingly specialised over the past 30 years or so, and specialist care has produced increasingly better outcomes for some patients. The patients left behind are looked after by general medicine, where demand is increasing, operational ...
openaire   +2 more sources

The [2Fe‐2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2‐regulated nitric oxide access tunnel

FEBS Letters, EarlyView.
The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang, Meritxell Wu‐Lu, Alberto Collauto, Peter‐Leon Hagedoorn, Madalina Alexandru, Maike Henschel, Shahram Kordasti, Maria Andrea Mroginski, Maxie M. Roessler, Kourosh H. Ebrahimi   +9 more
wiley   +1 more source

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, EarlyView.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source