Results 121 to 130 of about 423,513 (317)

Nonlinear time series models: consistency and asymptotic normality of nls under new conditions [PDF]

open access: yes, 1995
In this paper we study the consistency and asymptotic normality properties of nonlinear least squares (NLS) under a set of assumptions that are not difficult to verify.
Escribano, Álvaro, Mira, Santiago
core   +1 more source

Precise Control of Drug Release in Machine Learning‐Designed Antibody‐Eluting Implants for Postoperative Scarring Inhibition in Glaucoma

open access: yesAdvanced Healthcare Materials, EarlyView.
We developed a micro‐sized, biocompatible implant for postoperative sustained delivery of anti‐fibrotic antibodies in glaucoma surgery. Machine learning‐guided optimization of polymer composition, implant geometry, and porosity enabled precise control of drug release.
Mengqi Qin   +5 more
wiley   +1 more source

Specification Tests Based on Artificial Regressions [PDF]

open access: yes
Many specification tests can be computed by means of artificial linear regressions. These are linear regressions designed to be used as calculating devices to obtain test statistics and other quantities of interest.
James G. MacKinnon, Russell Davidson
core  

Metronidazole‐Loaded Cyclodextrin Nanogels for Antibacterial Therapy and Microbiota Regulation in Periodontitis

open access: yesAdvanced Healthcare Materials, EarlyView.
A methacrylamide β‐cyclodextrin‐based nanogel (MACD nGel) is developed to load the antimicrobial drug Metronidazole (MNZ) for topical delivery for the treatment of periodontitis. It is demonstrated that cyclodextrin nanogel (nGel) loaded with metronidazole provides an efficient drug delivery route but also has potential clinical applications and offers
Yanjing Ji   +8 more
wiley   +1 more source

Compression‐Tension‐Asymmetry and Stiffness Nonlinearity of Collagen‐Matrigel Composite Hydrogels

open access: yesAdvanced Healthcare Materials, EarlyView.
Self‐assembled collagen hydrogel matrices are widely used in tissue engineering applications. These matrices stiffen and contract laterally under tension due to fiber alignment and soften and collapse under compression due to fiber buckling. It is demonstrated that filler materials, such as Matrigel, linearize the mechanical behavior of collagen ...
David Böhringer   +9 more
wiley   +1 more source

Nonlinear regression applied for power quality disturbances characterization in grids with wind generators

open access: yesRE&PQJ
In  previous  researches,  the  large  signal  models  of  DC  microgrids  have  been  developed  without  using  any  time  averaging technique. Thus, the results obtained from available DC microgrid  large  signal  models  have  not  been  verified  by  results  from  their  detailed  models.  This  paper  presents  a  suitable  large  signal  model  
null M. Mahmoodi   +1 more
openaire   +2 more sources

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

open access: yesAdvanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour   +11 more
wiley   +1 more source

The Stochastic Fluctuation of the Quantile Regression Curve [PDF]

open access: yes
Let (X1, Y1), . . ., (Xn, Yn) be i.i.d. rvs and let l(x) be the unknown p-quantile regression curve of Y on X. A quantile-smoother ln(x) is a localised, nonlinear estimator of l(x).
Song Song, Wolfgang Härdle
core  

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

open access: yesAdvanced Healthcare Materials, EarlyView.
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins   +3 more
wiley   +1 more source

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