Results 81 to 90 of about 31,836,184 (250)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Oral Health-Related Quality of Life (OHRQoL) in Elderly Patients with and without Alzheimer’s Disease - An Evaluative Study

Indian Journal of Dental Research
Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterised by the loss of intellectual functions. The disorder is usually seen after the age of 60 years, and these elderly patients tend to experience a progressive ...
Ambar Khan, Rafia Untoo, Basavaraj Patthi, Ashish Singla, Monika Kumari, Ananthalekshmy Rajeev   +5 more
doaj   +1 more source

Oral health and quality of life among elderly in Thai

Journal of Dentistry Indonesia, 2016
Oral health contributes physically and psychologically to quality of life. Objective: To investigate the relationship of oral health status with oral health related and general Quality of Life (QOL) in elderly.
Patcharaphol Samnieng, Hatairat Lekatana
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Northern Territory oral health promotion plan, 2011-15

, 2011
The Northern Territory Oral Health Promotion Plan identifies key action areas and strategies to optimise the oral health of the community. It outlines actions at both the individual and population level and encourages collaboration between the ...
Oral Health Program, DoH
core   +1 more source

Percepção das condições de saúde bucal por gestantes atendidas em uma unidade de saúde no município de Araraquara, São Paulo, Brasil Oral health perception of pregnant women seen at a healthcare center in the municipality of Araraquara, São Paulo, Brazil

Revista Brasileira de Saúde Materno Infantil, 2006
OBJETIVOS: avaliar a percepção das condições de saúde bucal de um grupo de gestantes, através da aplicação do índice General Oral Health Assessment Index (GOHAI).
Silvio Rocha Corrêa da Silva, Fernanda Lopez Rosell, Aylton Valsecki Júnior   +2 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Design and evaluation of FEBS Education and Training Academy module – Integrating generative artificial intelligence into life‐science education

FEBS Open Bio, EarlyView.
Life‐science educators from 14 countries redesigned their own course materials with generative AI in a three‐session, pedagogy‐first FEBS Education and Training Academy workshop built on PICRAT. Among 12 matched respondents, four more reported high confidence in each of five practical domains, and 10 of 13 reported implementing at least one idea ...
Zvonimir Mlinarić, Ali Burak Özkaya
wiley   +1 more source

Construction of risk prediction model for dysphagia in hospitalized elderly patients with frailty

Frontiers in Medicine
BackgroundDysphagia is a common complication in elderly patients with frailty, affecting their prognosis and quality of life. Constructing a risk prediction model can help with early screening and intervention.ObjectiveTo investigate the current status ...
Yuzhu Lin, Chen Xu, Xue Song, Qin Tan, Xiaolei Lian   +4 more
doaj   +1 more source