Results 71 to 80 of about 1,270,255 (358)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Partnership law in the twenty-first century [PDF]

open access: yes, 2001
Discusses reforms to partnership law that have been proposed by the Law Commission and the Scottish Law Commission in their 'Partnership Law: a Joint Consultation Paper', and considers whether the reforms are necessary or not and what effect they are ...
Deards, E
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

ON THE SPECIFICS OF PUBLIC-PRIVATE PARTNERSHIP IN RUSSIAN AND FOREIGN PRACTICE

open access: yesВестник Северо-Кавказского федерального университета, 2022
The article examines the importance of public-private partnership at the current stage of development of the Russian economy. The basic features of the public-private partnership system in a number of leading countries of the world are studied.
R. Ustaev, V. Parakhina, Z. Shalashaa
doaj  

SPECIFICITIES OF CORPORATE GOVERNANCE IN SMALL BUSINESS ENTERPRISES OF UZBEKISTAN

open access: yesJournal of Management Small and Medium Enterprises (SME's), 2019
It is commonly known that the corporate governance is a way of management which is intrinsic to the large corporate structures. Today, in Uzbekistan such corporate structures mainly function in the form of joint-stock companies, limited liability ...
Zufar Ashurov
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Similar HIV protection from four weeks of zidovudine versus nevirapine prophylaxis among formula-fed infants in Botswana

open access: yesSouthern African Journal of HIV Medicine, 2018
Background: The World Health Organization HIV guidelines recommend either infant zidovudine (ZDV) or nevirapine (NVP) prophylaxis for the prevention of intrapartum motherto-child HIV transmission (MTCT) among formula-fed infants.
Kathleen M. Powis   +15 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

THE RELATIONSHIPS BETWEEN SUPPLIER PARTNERSHIP, ENVIRONMENTAL VARIABLES ANDFIRM PERFORMANCE IN RETAIL INDUSTRY

open access: yesGadjah Mada International Journal of Business, 2003
Partnership with suppliers is becoming a critical activity in retail industry to strengthen their competitive position. However, evidence suggested that partnership efforts do not reach their potential due to the effect of external factors.
Agus W. Soehadi
doaj   +1 more source

Toward a Real Simple Taxonomy: Bridging Learners and Content to Create New Value at LearnPhilanthropy [PDF]

open access: yes, 2012
LearnPhilanthropy is bringing together the wealth of research, resources and ideas on good practice from sources across the sector: Imagine a farmer's market providing fresh products from a variety of producers, all in one place, as well as a gathering ...
Dara Major
core  

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