Results 181 to 190 of about 16,433,437 (314)

Complex advance care planning intervention in general practice (ACP-GP) : a cluster-randomised controlled trial

Background Advance care planning (ACP) is an iterative communication process about patients’ preferences for future care. In general practice, there are barriers to ACP at patient, GP, and healthcare-system levels. A complex intervention may be necessary
Pype, PeterGE390001110008378020008792010000-0003-2273-02502C9D5B40-F0EE-11E1-A9DE-61C894A0A6B4, Eecloo, KimGE390020031854938020012323400000-0002-7984-411217463276-F0EE-11E1-A9DE-61C894A0A6B4, Stevens, JulieUGent0001410801338020030255279750970222200000-0002-1417-04365E2C247E-436D-11E4-90D2-E131B5D1D7B1, Miranda, RoseUGent8020025503289720562238815295D330-E352-11E6-B499-824DAE28A064, De Vleminck, AlineGE3900008053495580200098590113EC4A02-F0EE-11E1-A9DE-61C894A0A6B4, Pardon, KoenUGent802000967511977930461130325C548C-F0EE-11E1-A9DE-61C894A0A6B4, Deliens, LucUGent8010012873299725830854450000-0002-8158-242231DD76A8-F0EE-11E1-A9DE-61C894A0A6B4   +6 more
core  

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

General practice incentives: a review of the international literature. [PDF]

Br J Gen Pract
Harris M, Rhee J, Barr M, Sharma A, Harris-Roxas B, Burns M, Marshall K, Ali R, Sunjaya AP, van Kemenade C, Kidd M.   +10 more
europepmc   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Perverse incentives and ethical challenges for prescribing in English general practice. [PDF]

Br J Gen Pract
Parker J, Davies B.
europepmc   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Comparing the Knowledge and Awareness of Dental Students, Dental Practitioners and Patients About Botulinum Toxin and Its Therapeutic Applications in Temporomandibular Disorders

International Journal of Dentistry
Joshua Gower, Nihal Nayak, Jack Troy, Kobi Rutherford, Sanjay Vasudeva, Mahmoud M. Bakr   +5 more
doaj   +1 more source

Uncertainty in general practice: a myth of uniqueness? [PDF]

Fam Med Community Health
Tran M, Magin P, Hu W, Rhee J, Shulruf B.   +4 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source