Results 221 to 230 of about 2,286,294 (312)

Consultations in general practice related to a tick bite episode in mainland France in 2023-2024. [PDF]

BMC Public Health
Bonnet C, Launay T, Coustaury C, Septfons A, Durand J, Frey-Klett P, Warion S, Galon C, Moutailler S, Sevila J, Métras R, Debin M, Boëlle PY, Jaulhac B, Figoni J, Blanchon T, Falchi A.   +16 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Correction: Economic cost-benefit analysis of person-centred medicines reviews by general practice pharmacists. [PDF]

Int J Clin Pharm
O'Mahony C, Dalton K, O'Hagan L, Murphy KD, Kinahan C, Coyle E, Sahm LJ, Byrne S, Kirke C.   +8 more
europepmc   +1 more source

Studies of a General Practice [PDF]

BMJ, 1954
openaire   +2 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Extended Consultations as a Trial Intervention in General Practice: Experiences of Patients with Complex Multimorbidities. [PDF]

Patient Prefer Adherence
Fryd R, Barrett BA, Lundstrøm SL, Frølich A, Aamann IC.   +4 more
europepmc   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Evaluating clinical competencies of large language models with a general practice benchmark. [PDF]

Nat Commun
Li Z, Yang Y, Lang J, Jiang W, Chen J, Zhao Y, Li S, Wang D, Lin Z, Li X, Tang Y, Qiu J, Lu X, Yu H, Chen S, Bi Y, Zeng X, Chen Y, Yao L.   +18 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source