Results 51 to 60 of about 1,842,228 (287)
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Fractional div-curl quantities and applications to nonlocal geometric equations
, 2017 We investigate a fractional notion of gradient and divergence operator. We generalize the div-curl estimate by Coifman-Lions-Meyer-Semmes to fractional div-curl quantities, obtaining, in particular, a nonlocal version of Wente's lemma.
Adams +55 more
core +1 more source
Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source
Quantification in Ordinary Language and Proof Theory
Philosophia Scientiæ, 2016 This paper gives an overview of the common approach to quantification and generalised quantification in formal linguistics and philosophy of language. We point out how this usual general framework represents a departure from empirical linguistic data. We
Michele Abrusci +2 more
doaj +1 more source
Discovery of Invariants through Automated Theory Formation [PDF]
Electronic Proceedings in Theoretical Computer Science, 2011 Refinement is a powerful mechanism for mastering the complexities that arise when formally modelling systems. Refinement also brings with it additional proof obligations -- requiring a developer to discover properties relating to their design decisions ...
Andrew Ireland +2 more
doaj +1 more source
Gauge invariance of massless QED
, 1994 A simple general proof of gauge invariance in QED is given in the framework of causal perturbation theory. It illustrates a method which can also be used in non-abelian gauge theories.Comment: 7 pages, TEX-file, Zuerich University Preprint ZU-TH-33 ...
Blanchard +10 more
core +1 more source
Arthritis Care &Research, Accepted Article.Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos +2 more
wiley +1 more source