Results 31 to 40 of about 259,097 (230)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Symmetry breaking in general relativity [PDF]

, 1980
Bifurcation theory is used to analyze the space of solutions of Einstein's equations near a spacetime with symmetries. The methods developed here allow one to describe precisely how the symmetry is broken as one branches from a highly symmetric spacetime
Fischer, Arthur E., Marsden, Jerrold E., Moncrief, Vincent   +2 more
core  

Electromagnetic duality in general relativity

, 1999
By resolving the Riemann curvature relative to a unit timelike vector into electric and magnetic parts, we consider duality relations analogous to the electromagnetic theory.
A. K. Raychaudhuri, C. W. Misner, D. Lynden-Bell, D. Notzold, L. Bel, M. A. G. Bonilla, M. Barriola, M. Nouri-Zonoz, N. Dadhich, N. Dadhich, N. Dadhich, N. Dadhich, N. Dadhich, N. Dadhich, N. Dadhich, N. Dadhich, Naresh Dadhich, R. L. Davis, S. Chandrasekhar   +18 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Chern-Simons Modified General Relativity

, 2009
Chern-Simons modified gravity is an effective extension of general relativity that captures leading-order, gravitational parity violation. Such an effective theory is motivated by anomaly cancelation in particle physics and string theory. In this review,
Adler, Aichelburg, Alexander, Alexander, Alexander, Alexander, Alexander, Alexander, Alexander, Alexander, Alvarez-Gaume, Ashtekar, Ashtekar, Balasin, Balasin, Barbero, Barrabes, Battefeld, Bell, Belyaev, Bender, Bergshoeff, Blanchet, Brandenberger, Brandenberger, Brandenberger, Brax, Brunfiel, Burgay, Cabella, Campbell, Campbell, Campbell, Campbell, Cantcheff, Carroll, Carroll, Carroll, Carroll, Cherubini, Choi, Ciufolini, Ciufolini, Cunningham, Damour, Danzmann, Danzmann, Deser, Deser, Dimopoulos, Dolgov, Dolgov, Feng, Finn, Finn, Fischler, Freidel, Fujikawa, Fujikawa, Fukugita, Furtado, Garcia, Gerlach, Gerlach, Gibbons, Gomes, Gradshteyn, Green, Green, Green, Grumiller, Grumiller, Guarrera, Gukov, Holst, Huet, Hulse, Immirzi, Iorio, Israel, Jackiw, Jones, Jordan, Kaloper, Kamionkowski, Kamionkowski, Kevorkian, Konno, Konno, Konno, Kostelecky, Kostelecky, Kramer, Kuzmin, Lanczos, Lanczos, Lemoine, Lichnerowicz, Lousto, Lue, Lukács, Lyddle, Lyth, Mann, Mann, Mariz, Mariz, Markevitch, Martin, Martin, Martin, Mashhoon, Matte, Mcallister, Mercuri, Mercuri, Mercuri, Mercuri, Mercuri, Miller, Misner, Misner, Moncrief, Montenbruck, Mukhanov, Murray, Nayeri, Nicolás Yunes, Nordtvedt, Nordtvedt, Penrose, Perez, Poisson, Polchinski, Randono, Randono, Regge, Reuter, Richter, Riess, Romano, Rubin, Rubin, Saito, Sakharov, Schiff, Smith, Sopuerta, Sopuerta, Spergel, Stephani, Stephon Alexander, Sumner, Svrcek, Taveras, Thiemann, Thorne, Tseytlin, Wald, Wesley, Will, Will, Will, Will, Will, Will, Wittman, Xia, Yang, Yunes, Yunes, Yunes, Yunes, Yunes, Yunes, Zerilli   +175 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Discrete Hamiltonian for General Relativity

, 2015
Beginning from the Ashtekar formulation of canonical general relativity, we derive a physical Hamiltonian written in terms of (classical) loop gravity variables.
Gegenberg, Jack, Ziprick, Jonathan
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source