Promising general solution to the problem of ligating peptides and glycopeptides. [PDF]
J Am Chem Soc, 2010 Wang P, Danishefsky SJ.
europepmc +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
An enumerative method for the solution of linear complementarity problems
, 1983 In this report an enumerative method for the solution of the Linear Complementarity Problem (LCP) is presented. This algorithm completely processes the LCP, and does not require any particular property of the LCP to apply.
Mitra, G, Judice, JJ
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Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Determinants of General Practitioners' Wages in England [PDF]
We analyse the determinants of annual net income and wages (annual net income/hours) of general practitioners (GPs) using a unique, anonymised, non-disclosive dataset derived from tax returns for 21,657 GPs in England for the financial year 2002/3.
Hugh Gravelle +7 more
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A General Solution to the Continuum Rate Equation for Island-Size Distributions: Epitaxial Growth Kinetics and Scaling Analysis. [PDF]
Nanomaterials (Basel)Dubrovskii VG.
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FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Solution of Different Types of Economic Load Dispatch Problems Using a Pattern Search Method
, 2008 Direct search (DS) methods are evolutionary algorithms used to solve constrained optimization problems. DS methods do not require information about the gradient of the objective function when searching for an optimum solution.
Sykulski, J.K. +2 more
core
A general solution for electromechanical analysis of electroelastic composite plates with arbitrary holes. [PDF]
HeliyonRao DKN +5 more
europepmc +1 more source