Results 181 to 190 of about 2,633 (230)

Information Design for Early‐Stage Dose‐Finding Trials

open access: yesNaval Research Logistics (NRL), EarlyView.
ABSTRACT To enhance enrollment rates in early‐stage dose‐finding clinical trials, we propose an information design approach, where the clinical investigator (CI) commits to an information releasing mechanism (IRM) based on the treatment's uncertain efficacy and toxicity to encourage patients to participate in the trial.
Amin Khademi, Ningyuan Chen
wiley   +1 more source

Optimal Designs and Inspection Time Decisions for Gamma Accelerated Degradation Tests

open access: yesNaval Research Logistics (NRL), EarlyView.
ABSTRACT This study analytically derives optimal designs for gamma accelerated degradation tests while incorporating inspection time as a design variable under both D‐ and V‐optimality criteria. Under D‐optimality, we prove that the optimal design allocates test units exclusively to the lowest and highest stress levels and adopts the longest inspection
Hung‐Ping Tung, I‐Chen Lee
wiley   +1 more source

Allocation of Indivisible Items With a Common Preference Graph: Minimizing Total Dissatisfaction

open access: yesNetworks, EarlyView.
ABSTRACT Allocating indivisible items among a set of agents is a frequently studied discrete optimization problem. In the setting considered in this work, the agents' preferences over the items are assumed to be identical. We consider a very recent measure for the overall quality of an allocation which does not rely on numerical valuations of the items.
Nina Chiarelli   +6 more
wiley   +1 more source

Generalizing the Gaussian Network Model: Spanning‐Tree Thermodynamics Shows Entropy‐Driven KRAS Activation

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The GTPase KRAS executes a conformational switch between a GTP‐bound active state and a GDP‐bound inactive state, a process central to oncogenic signaling. However, the structural basis of this switching at the level of residue‐contact organization remains incompletely characterized by traditional binary structural models.
Fatma Senguler Ciftci, Burak Erman
wiley   +1 more source

Adaptive Sliding‐Mode Control of a Perturbed Diffusion Process With Pointwise In‐Domain Actuation

open access: yesInternational Journal of Robust and Nonlinear Control, EarlyView.
ABSTRACT A sliding mode–based adaptive control law is proposed for a class of diffusion processes featuring a spatially‐varying uncertain diffusivity and equipped with several point‐wise actuators located at the two boundaries of the spatial domain as well as in its interior.
Paul Mayr   +3 more
wiley   +1 more source

Optimal Homogeneous ℒp$$ {\boldsymbol{\mathcal{L}}}_{\boldsymbol{p}} $$‐Gain Controller

open access: yesInternational Journal of Robust and Nonlinear Control, EarlyView.
ABSTRACT Nonlinear ℋ∞$$ {\mathscr{H}}_{\infty } $$‐controllers are designed for arbitrarily weighted, continuous homogeneous systems with a focus on systems affine in the control input. Based on the homogeneous ℒp$$ {\mathcal{L}}_p $$‐norm, the input–output behavior is quantified in terms of the homogeneous ℒp$$ {\mathcal{L}}_p $$‐gain as a ...
Daipeng Zhang   +3 more
wiley   +1 more source

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