Results 51 to 60 of about 440,760 (255)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Świadomość jako system względnie izolowany. U podstaw Ingardenowej ontologii umysłu (Consciousness as a relatively isolated system. Fundamentals of Ingardenian ontology of mind) [PDF]
Analiza i Egzystencja, 2010 The analyses Ingarden had carried out of relatively isolated systems are important from the point of view of the ontology of mind as they lead to a precise description of the form and the mode of existence of consciousness within the multilevel structure
Robert Poczobut
doaj
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Emergence of Edgar Morin’s Complex Thinking [PDF]
Anais da Academia Brasileira de CiênciasEdgar Morin is more than 100 years old and has produced numerous original ideas. Complex Thinking is his approach to complexity and took almost thirty years to be written.
ENIO A. BLAY, JOSÉ ROBERTO C. PIQUEIRA
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Hardiness of introduced plants from a position of general theory of systems
Інтродукція Рослин, 2000 Theoretical aspects of hardiness of introduced plants are considered from a position of system analysis. The conception of complex hardiness is developed. Some methods for this conception determination are proposed.
P.E. Bulakh
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
ReligionsFor most, the way to process thought has been through mathematician-turned-philosopher Alfred North Whitehead (1861–1947). However, his contemporary, Swedish–American philosopher John Elof Boodin (1869–1950), offers another path.
Michael A. Flannery
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source