Results 81 to 90 of about 440,760 (255)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

A deformation theory approach to linear systems with general triple point

Le Matematiche, 2000
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Ciro Ciliberto, Rick Miranda
doaj  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

General System Theory: the Biotic Systems, Basic Concepts, Laws of Functioning

Медицинский вестник Юга России, 2011
This article presents a short review of historical background for the creation of the general theory of systems. There are also given basic statements of this theory and as well her scientific significance in the field of scientific facts’ synthesis is ...
T. L. Botasheva, A. V. Chernositov, O. P. Zavodnov, E. B. Gudz   +3 more
doaj  

Conceptual model for universal bibliographic control

JLIS.it
A proposal is presented for a conceptual model of universal bibliographic control based on general systems theory (GST) and considered as a global system with a decentralized, distributed, collaborative, interconnected and linked model structure.
Sandra Gisela Martin
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Evolution of convective clouds in terms of the general systems theory

Moldavian Journal of the Physical Sciences, 2012
Some features (laws) of the evolution of convective clouds fit into and are summarized in terms of a simple "resourceconsumer" Lotka – Volterra model. Based on this model, taking into account the revealed system-wide patterns, we analyze the possibility
Potapov, Evghenii, Potapov, Evghenii, Stepaniatov, Iurii, Komenko, A.   +3 more
doaj  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Method of general Сoule-Hopf substitutions in theory of finite-dimensional dynamical systems

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2011
We consider the results of applying the method of generic Cole-Hopf substitutions to integration of finite-dimensional dynamical systems. Dynamical systems are represented in the form of matrix ordinary differential equations with specific matrix algebra
Victor M Zhuravlev, Konstantin S Obrubov
doaj