Results 31 to 40 of about 119,991 (198)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

A robust computational study for assessing the dynamics and control of emerging zoonotic viral infection with a case study: A novel epidemic modeling approach

AIP Advances
Fractional calculus and fractal theory remain significant tools in modeling complex real-world problems in biology and life science. In this study, we formulated a compartmental mathematical model using the Caputo fractional and fractal–fractional ...
Shuo Li, Saif Ullah, Samreen, Ihsan Ullah Khan, Salman A. AlQahtani, Muhammad Bilal Riaz   +5 more
doaj   +1 more source

Bounds on the non-real spectrum of differential operators with indefinite weights [PDF]

, 2012
Ordinary and partial differential operators with an indefinite weight function can be viewed as bounded perturbations of non-negative operators in Krein spaces.
Behrndt, Jussi, Philipp, Friedrich, Trunk, Carsten   +2 more
core   +1 more source

Bispectral algebras of commuting ordinary differential operators

, 1996
We develop a systematic way for constructing bispectral algebras of commuting ordinary differential operators of any rank $N$. It combines and unifies the ideas of Duistermaat-Gr\"unbaum and Wilson.
Bakalov, B., Horozov, E., Yakimov, M.
core   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi‐ and contra‐lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post‐ICH ambulation.
Yasmin N. Aziz, Carl D. Langefeld, Mary E. Comeau, Miranda C. Marion, Tyler P. Behymer, Lee A. Gilkerson, Padmini Sekar, Weihong Yuan, Vivek Khandwala, Brady J. Williamson, Thomas Maloney, Achala Vagal, Pierce Boyne, Kari Dunning, Matthew L. Flaherty, Steven J. Kittner, Prachi Mehndiratta, Gunjan Y. Parikh, Michael L. James, David Roh, Fernando D. Testai, Farhaan S. Vahidy, James Thornton, Ranjit Bagga, Daniel Woo, Stacie L. Demel   +25 more
wiley   +1 more source

Generalized fractional integration of the \overline{H}-function

Le Matematiche, 2012
A significantly large number of earlier works on the subject of fractional calculus give interesting account of the theory and applications of fractional calculus operators in many different areas of mathematical analysis (such as ordinary and partial ...
Praveen Agarwal
doaj  

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Huygens' Principle in Minkowski Spaces and Soliton Solutions of the Korteweg-de Vries Equation

, 1997
A new class of linear second order hyperbolic partial differential operators satisfying Huygens' principle in Minkowski spaces is presented. The construction reveals a direct connection between Huygens' principle and the theory of solitary wave solutions
Berest, Y., Loutsenko, I.
core   +2 more sources