Results 31 to 40 of about 4,586 (235)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Generalized fractional integration of the \overline{H}-function

open access: yesLe Matematiche, 2012
A significantly large number of earlier works on the subject of fractional calculus give interesting account of the theory and applications of fractional calculus operators in many different areas of mathematical analysis (such as ordinary and partial ...
Praveen Agarwal
doaj  

Parity and generalized multiplicity [PDF]

open access: yes, 1991
Assuming that X and Y are Banach spaces and that T is a path of linear Fredholm operators with invertible endpoints, in [F-Pl] we defined a homotopy invariant "the parity of T .
Fitzpatrickp.   +2 more
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Existence and Uniqueness Results for a Kirchhoff Double-Phase Problem Involving the ψ-Hilfer Derivative

open access: yesMathematics
This work develops an analytical framework for nonlinear fractional partial differential equations that combine Kirchhoff-type terms, double-phase operators, and ψ-Hilfer fractional derivatives.
Najla Mohammed Alghamdi
doaj   +1 more source

Differential symmetry breaking operators I : General theory and F-method

open access: yes, 2016
International audienceWe prove a one-to-one correspondence between differential symmetry breaking operators for equivariant vector bundles over two homogeneous spaces and certain homomorphisms for representations of two Lie algebras, in connection with ...
Kobayashi, Toshiyuki   +3 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Ricci-corrected derivatives and invariant differential operators [PDF]

open access: yes, 2005
We introduce the notion of Ricci-corrected differentiation in parabolic geometry, which is a modification of covariant differentiation with better transformation properties.
Souček, Vladimír   +4 more
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Applications of the integral transforms composition method to wave-type singular differential equations and index shift transmutations

open access: yesElectronic Journal of Differential Equations, 2018
In this article we study applications of integral transforms composition method (ITCM) for obtaining transmutations via integral transforms. It is possible to derive wide range of transmutation operators by this method.
Ahmed Fitouhi   +3 more
doaj  

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