Results 21 to 30 of about 117 (94)
New biosensors and transgenic mice for multiplex cGMP imaging
British Journal of Pharmacology, EarlyView.Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters +6 more
wiley +1 more source
Near Surface Geophysics, Volume 24, Issue 2, Page 110-127, April 2026.Abstract As global groundwater levels continue to decline rapidly, there is a growing need for advanced techniques to monitor and manage aquifers effectively. This study focuses on validating a numerical model using seismic data from a small‐scale experimental setup designed to estimate water volume in a porous reservoir.
Mahnaz Khalili +8 more
wiley +1 more source
Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials
British Journal of Pharmacology, Volume 183, Issue 7, Page 1364-1389, April 2026.Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen +2 more
wiley +1 more source
Breaking Barriers in High‐Order Spectral Methods: The Intrinsic Matrix Approach
International Journal for Numerical Methods in Engineering, Volume 127, Issue 5, 15 March 2026.ABSTRACT This paper introduces a unified framework in Hilbert spaces for applying high‐order differential operators in bounded domains using Chebyshev, Legendre, and Fourier spectral methods. By exploiting the banded structure of differentiation matrices and embedding boundary conditions directly into the operator through a scaling law relating ...
Osvaldo Guimarães, José R. C. Piqueira
wiley +1 more source
Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium
Advanced Science, Volume 13, Issue 14, 9 March 2026.This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du +5 more
wiley +1 more source
Advanced Science, Volume 13, Issue 16, 18 March 2026.Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao +3 more
wiley +1 more source
Ghost effect from Boltzmann theory
Communications on Pure and Applied Mathematics, Volume 79, Issue 3, Page 558-675, March 2026.Abstract Taking place naturally in a gas subject to a given wall temperature distribution, the “ghost effect” exhibits a rare kinetic effect beyond the prediction of classical fluid theory and Fourier law in such a classical problem in physics. As the Knudsen number ε$\varepsilon$ goes to zero, the finite variation of temperature in the bulk is ...
Raffaele Esposito +3 more
wiley +1 more source
Optimal Control Applications and Methods, Volume 47, Issue 2, Page 570-588, March/April 2026.Implicit third‐order Peer two‐step methods that are superconvergent for variable stepsizes have the potential to significantly improve the efficiency of solving large‐scale ODE‐constrained optimal control problems. These include real‐world applications in medical treatment planning for prostate cancer, such as the design of effective three‐dose drug ...
Jens Lang, Bernhard A. Schmitt
wiley +1 more source
Interpretable Machine Learning: A Comprehensive Review of Foundations, Methods, and the Path Forward
WIREs Data Mining and Knowledge Discovery, Volume 16, Issue 1, March 2026.This systematic review of 352 studies establishes a comprehensive taxonomy for Interpretable Machine Learning, transitioning from foundational intrinsic models to advanced deep learning explanations. It reveals a critical paradigm shift toward “mechanistic interpretability” and actionable recourse, emphasizing that future AI systems must be rigorously ...
Shimon Fridkin, Michael Bendersky
wiley +1 more source
Fourier Neural Operator for Moonquake Detection
Earth and Space Science, Volume 13, Issue 3, March 2026.Abstract Moonquakes provide critical observations for probing the lunar interior, yet their analysis is hindered by the limited number of recordings and their inherently low signal‐to‐noise ratio (S/N). Conventional detection methods such as Short‐Term Average/Long‐Term Average (STA/LTA) perform poorly on lunar data, while standard deep learning models
Basem Al‐Qadasi, Umair Bin Waheed
wiley +1 more source