Results 161 to 170 of about 870,132 (295)

LaRue County - General History

, 1939
A brief historical survey of LaRue County, Kentucky conducted by the Works Progress ...
Works Progress Administration
core  

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Pain and Prose: Tracing the Opioid Epidemic in Stephen King's Novels. [PDF]

Nordisk Alkohol Nark
Marquez-Romero JM.
europepmc   +1 more source

Powell County - General History

, 1939
A brief historical survey of Powell County, Kentucky conducted by the Works Progress ...
Works Progress Administration
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Greenup County - General History

, 1939
A brief historical survey of Greenup County, Kentucky conducted by the Works Progress Administration in the late ...
Works Progress Administration
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Postpartum well-being in hemophilia carriers and women with von Willebrand disease: insights from patient-reported outcome measures. [PDF]

Res Pract Thromb Haemost
de Vaan A, Doeff EA, Eikenboom J, Kruip MJHA, Punt MC, Coppens M, Nieuwenhuizen L, Schols SEM, Mäkelburg ABU, Heubel-Moenen FCJI, Duvekot HJ, Peters M, Middeldorp A, Bloemenkamp KWM, Schutgens REG, van Galen KPM.   +15 more
europepmc   +1 more source

Hanford Works Report HW-61780

, 1959
The region in which Hanford's chemical processing plant areas (separation areas) are located in the central portion of the Hanford Works area on a plateau, shaped like a giant bar, of glaciofluviatile materials.
Brown, D. J.
core  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source