Results 111 to 120 of about 1,592,426 (314)
BioMedInformaticsArtificial Intelligence (AI) and deep learning models have revolutionized diagnosis, prognostication, and treatment planning by extracting complex patterns from medical images, enabling more accurate, personalized, and timely clinical decisions.
Anh T. Tran +2 more
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A Generalization of the Doubling Construction for Sums of Squares Identities [PDF]
, 2017 Chi Zhang, Hua-Lin Huang
openalex +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Performance Evaluation of Different Speech-Based Emotional Stress Level Detection Approaches
IEEE AccessThis study presents a comprehensive evaluation and comparison of selected conventional and advanced approaches for detecting and classifying emotional stress levels from speech.
Jan Stas, Stanislav Ondas, Jozef Juhar
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Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The Geometry of Thought: Circling Through Concepts
PhilosophiesThe goal of this paper is to shed light on the nature of mathematical practice, i.e., on “doing mathematics”. It explores Gödel’s perspective, which offers an approach to understanding mathematics centered on concepts, objects, and structures.
Miloš Adžić +2 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
AMaze: an intuitive benchmark generator for fast prototyping of generalizable agents
Frontiers in Artificial IntelligenceTraditional approaches to training agents have generally involved a single, deterministic environment of minimal complexity to solve various tasks such as robot locomotion or computer vision.
Kevin Godin-Dubois +2 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source