Results 111 to 120 of about 589,363 (249)
Inverting magnetotelluric data using a physics-guided auto-encoder with scaling laws extension
Frontiers in Earth ScienceArtificial neural networks (ANN) have gained significant attention in magnetotelluric (MT) inversions due to their ability to generate rapid inversion results compared to traditional methods.
Lian Liu, Bo Yang, Yi Zhang
doaj +1 more source
The impact of emotional valence on generalization gradients [PDF]
Generalization enables individuals to respond to novel stimuli based on previous experiences. The degree to which organisms respond is determined by their physical resemblance to the original conditioned stimulus (CS+), with a stronger response elicited ...
Martínez-Tomás, Celia +5 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Adversarial Validation in Image Classification Datasets by Means of Cumulative Spectral Gradient
AlgorithmsThe main objective of a machine learning (ML) system is to obtain a trained model from input data in such a way that it allows predictions to be made on new i.i.d. (Independently and Identically Distributed) data with the lowest possible error.
Diego Renza +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Generalization in fifth graders within a functional approach
PNA: Revista de Investigación en Didáctica de la Matemática, 2018 This article discusses evidence of 24 fifth graders’ (10-11 year olds’) ability to generalize when solving a problem which involves a linear function. Analyzed in the context of the functional approach of early algebra, the findings show that 3 students ...
Eder Pinto, María C. Cañadas
doaj
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Layers of generality and types of generalization in pattern activities [PDF]
, 2010 Pattern generalization is considered one of the prominent routes for in-troducing students to algebra. However, not all generalizations are al-gebraic. In the use of pattern generalization as a route to algebra, we —teachers and educators— thus have to ...
Radford, Luis
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source