Results 161 to 170 of about 79,064 (268)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Reply to the Letter to the editor by Malatesta, Alessandria, Berrino and Donzelli. [PDF]

EXCLI J
Manzoli L, Acuti Martellucci C, Flacco ME.   +2 more
europepmc   +1 more source

Validating Generalizations about AI and Its Uses

Many discussions of the tremendously important topic of AI are undermined by vague definitions of what AI is and by generalizations that are too distant from reality to be useful when pursuing or evaluating real world applications.
Alter, Steven
core  

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

We Do Not Speak Like This Here: The Role of Perceived Foreignness in Shaping Speaker-Specific Social and Linguistic Inferences. [PDF]

Cogn Sci
Trainin N, Shetreet E.
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Wigner Functions of Time-Dependent Cat-like Even/Odd Superpositions of Nonlinear Coherent States. [PDF]

Entropy (Basel)
de Freitas MC, Dodonov VV.
europepmc   +1 more source

Moral Generalizations and Moral Explanatory Pluralism

I argue that moral principles, construed as moral generalizations, can be genuinely explanatory. Specifically, I present and respond to a challenge according to which moral generalizations are explanatorily redundant. In response, I present and defend an
Stamatiadis-Bréhier, Alexios
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Special Issue "Polymeric Materials for Biomedical Applications, Drug and Gene Delivery". [PDF]

Int J Mol Sci
Nifant'ev IE.
europepmc   +1 more source