Results 41 to 50 of about 75,878 (214)
, 2020 Additional file 2: (A) Amino acid sequence alignment of PckA in A. tumefaciens C58, B. ovis 63/290, B. abortus 2308 and B. suis 513. In bold and underlined, the specific domain (IGGTSYAGE-KKS; 190 to 202) required for the PckA activity, the phosphate-binding (G--G-GKT; 233 to 243) and adenine-binding (IIML—D; 345 to 351) consensus sites of ATP ...
Vizcaíno, Nieves +5 more
openaire +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Nonparametric Independence Screening in Sparse Ultra-High Dimensional Additive Models [PDF]
, 2010 A variable screening procedure via correlation learning was proposed Fan and Lv (2008) to reduce dimensionality in sparse ultra-high dimensional models. Even when the true model is linear, the marginal regression can be highly nonlinear.
Fan, Jianqing, Feng, Yang, Song, Rui
core +1 more source
, 2020 Additional file 1: Chemically defined media used in this work.
Vizcaíno, Nieves +5 more
openaire +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Causal Discovery with Continuous Additive Noise Models [PDF]
, 2014 We consider the problem of learning causal directed acyclic graphs from an observational joint distribution. One can use these graphs to predict the outcome of interventional experiments, from which data are often not available.
Janzing, Dominik +3 more
core +3 more sources
Entropy: The Markov Ordering Approach
, 2013 The focus of this article is on entropy and Markov processes. We study the properties of functionals which are invariant with respect to monotonic transformations and analyze two invariant "additivity" properties: (i) existence of a monotonic ...
Aczel +35 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
, 2017 Supplementary Tables and Figures. Table S1. Total and mapped reads produced for each ChIP-seq sample. Table S2. Primers used for ChIP qPCR. Figure S1. Comparison of H2AK121ub and H3K27me3 ChIP-seq replicates in WT Arabidopsis seedlings at 7 DAG. Figure S2. Identification of H2AK121ub peaks. Figure S3.
Zhou, Yue +4 more
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source