Results 111 to 120 of about 281,620 (281)

Efficient estimation of generalized additive nonparametric regression models. [PDF]

We define new procedures for estimating generalized additive nonparametric regression models that are more efficient than the Linton and Härdle (1996, Biometrika 83, 529–540) integration-based method and achieve certain oracle bounds.
Linton, Oliver
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Linking watershed nutrient loading to estuary water quality with generalized additive models. [PDF]

PeerJ, 2023
Schramm MP.
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Recovering Gamma-Ray Burst Redshift Completeness Maps via Spherical Generalized Additive Models

Universe
We present an advanced statistical framework for estimating the relative intensity of astrophysical event distributions (e.g., Gamma-Ray Bursts, GRBs) on the sky tofacilitate population studies and large-scale structure analysis.
Zsolt Bagoly, Istvan I. Racz
doaj   +1 more source

Central adiposity as a predictor of mortality in older adults: Identification of cutoffs using generalized additive models. [PDF]

Front Nutr, 2023
Fernandes DPS, Lopes Juvanhol L, Nobre AA, de Souza ÂMN, Ribeiro AQ.   +4 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Blowing in the wind? Testing the effect of weather on the spatial distribution of crime using Generalized Additive Models. [PDF]

Crime Sci, 2022
Hart R, Pedersen W, Skardhamar T.
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Generalized Additive Models

Annual Review of Statistics and Its Application
Generalized additive models are generalized linear models in which the linear predictor includes a sum of smooth functions of covariates, where the shape of the functions is to be estimated. They have also been generalized beyond the original generalized linear model setting to distributions outside the exponential family and to situations in which ...
openaire   +1 more source