Results 71 to 80 of about 2,480,441 (296)

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Basic pharmacology of generalized anxiety disorder

, 2014
Generalized anxiety disorder (GAD) is a chronic, disabling condition in which treatment response is often unsatisfactory. Aetiology and underlying mechanisms of GAD, as for most psychiatric disorders, remain relatively poorly understood.
Schepisi, C., Nistic(\`o), R., Mango, D., Nicoletti, F.   +3 more
core   +1 more source

Anxiety Disorder, Generalized Anxiety Disorder, Social Anxiety Disorder

, 2021
Social anxiety disorder Social anxiety disorder, formerly known as social anxiety disorder, was, until the 1960s, a fear of public behavior (mostly public speech) and was only part of the phobia. ..
Aidan Nash
core   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Disabling employment obstacles: a study exploring accommodations that can assist government employees with anxiety [PDF]

, 2015
This policy bulletin summarises the findings of a study which examined the work experiences of Queensland public servants living with a diagnosed anxiety disorder.   Key findings are: Workplace accommodations tailored to individuals with anxiety
Jennifer Smith-Merry, Justin Scanlan, Damian Mellifont   +2 more
core  

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Efficacy of combined treatment based on acceptance and commitment in treatment of women with generalized anxiety disorder

مجله دانشگاه علوم پزشکی گرگان, 2017
Background and Objective: General anxiety disorder is one of the chronic disorders in the general population and population with clinical symptoms. This study was conducted to evaluate the efficacy of combined treatment based on acceptance and commitment
Majid Mahmoud Alilou, Touraj Hashemi Nosratabad, Faeze Sohrabi   +2 more
doaj  

Generalized anxiety disorder (GAD) and anxiety symptoms in older adults [PDF]

, 2019
Anxiety is a broad concept, difficult to detect and recognize. Expression may shift over the lifetime further complicating identification. Generalized Anxiety Disorder (GAD) is one of the most common anxiety disorders in older adults; however, the true ...
Nilsson, Johan
core   +1 more source

Expert Consensus on the Management of Obesity in Older Adults (2026 Edition)

AGING MEDICINE, EarlyView.
This graphical abstract summarizes a safety‐first framework for managing obesity in older adults, with attention to age, functional status, comorbidities, and sarcopenia risk. Key assessments include BMI, waist measures, body fat percentage, skeletal muscle mass, and comprehensive geriatric evaluation. Management prioritizes reducing visceral fat while
Qi Pan, Lixin Guo
wiley   +1 more source