Results 21 to 30 of about 152 (81)

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean‐Christoph Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

Clinical Features and Drug Characteristics of Patients with Generalized Fixed Drug Eruption in the West of Iran (2005–2014)

Dermatology Research and Practice, Volume 2015, Issue 1, 2015., 2015
Background. Generalized fixed drug eruption is a specific variant of fixed drug eruption with multifocal lesions. Diagnosis of this drug reaction is straightforward, but occasionally recognition of the causative drug is not possible. This study was aimed at evaluating the clinical features and culprit drugs in generalized fixed drug eruptions in the ...
Hossein Kavoussi, Mansour Rezaei, Katayoun Derakhshandeh, Alireza Moradi, Ali Ebrahimi, Harif Rashidian, Reza Kavoussi, Craig G. Burkhart   +7 more
wiley   +1 more source

The Use of Etanercept in the Palliative Treatment of a Patient With Generalised Bullous Fixed Drug Eruption

Australasian Journal of Dermatology, Volume 66, Issue 7, Page e471-e473, November 2025.
ABSTRACT Generalised Bullous Fixed Drug Eruption (GBFDE) is a subtype of Fixed Drug Eruption (FDE) characterised by the development of generalised blisters on the background of dusky macules. There is no gold standard treatment, but the condition is conventionally managed with supportive care, topical and oral steroids and occasionally ciclosporin.
Olga Pawlik, Timothy Cowan, Andrew Miller   +2 more
wiley   +1 more source

Drug‐Induced Periocular and Ocular Surface Disorders: An EAACI Position Paper

Allergy, Volume 80, Issue 11, Page 2953-2972, November 2025.
ABSTRACT Various systemic and topical medications can induce ocular and periocular cutaneous adverse effects (AEs), ranging from mild to severe. These AEs may lead to ocular surface (OS) damage and, in some cases, life‐threatening complications. Drug‐induced ocular adverse reactions are generally classified into two primary categories: toxic reactions ...
Andrea Leonardi, Banu Bozkurt, Diana Silva, Charlotte G. Mortz, Christophe Baudouin, Marina Atanaskovic‐Markovic, Vibha Sharma, Serge Doan, Shweta Agarwal, Daniel Pérez‐Formigo, Maria Joao Vasconcelos, Francoise‐Brignole Baudouin, Gonzalo Chorzepa, Jean‐Luc Fauquert, Virginia Calder, Pascal Demoly, Luis Delgado   +16 more
wiley   +1 more source

Feedback regulation of VISTA and Treg by TNF‐α controls T cell responses in drug allergy

Allergy, Volume 80, Issue 5, Page 1400-1416, May 2025.
TNF‐α breaks immune tolerance by regulating the VISTA at early stage of the drug‐specific T cell response. The response of drug‐responsive effector T cells was negative feedback regulated by increasing Treg cells. This indicates that Treg agonists, rather than TNF‐α antagonists, could be used to treat patients with progressive SCARs. Abbreviations: HLA,
Lele Sun, Qing Zhao, Suiting Ao, Tingting Liu, Zhenzhen Wang, Jiabao You, Zihao Mi, Yonghu Sun, Xiaotong Xue, Monday O. Ogese, Joshua Gardner, Xiaoli Meng, Dean J. Naisbitt, Hong Liu, Furen Zhang   +14 more
wiley   +1 more source

S3 guideline: Diagnosis and treatment of epidermal necrolysis (Stevens‐Johnson syndrome and toxic epidermal necrolysis) – Part 1: Diagnosis, initial management, and immunomodulating systemic therapy

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 22, Issue 10, Page 1448-1466, October 2024.
Summary Stevens‐Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are rare, predominantly drug‐induced, acute, life‐threatening diseases of skin and mucosae. SJS and TEN are nowadays considered variants of one disease entity with varying degrees of severity called epidermal necrolysis (EN). EN is associated with high morbidity and mortality and
Ruben Heuer, Maren Paulmann, Thorsten Annecke, Björn Behr, Katharina Boch, Anja M. Boos, Knut Brockow, Lars E. French, Jochen Gille, Verena Gundlach, Bernd Hartmann, Peter Höger, Silke C. Hofmann, Tobias Klein, Marcus Lehnhardt, Yvonne Liß, Philip Maier, Philipp Mandel, Nicos Marathovouniotis, Finnja Marlok, Hans Mittelviefhaus, Uwe Pleyer, Marie Pradeau, Katharina Rall, Siegbert Rieg, Heike Rittner, Frank Sander, Stefan Schnitzler, Christina Schut, Annette Stolle, Artem Vorobyev, Bettina Wedi, Johannes Weiss, Maximilian Zepp, Mirjana Ziemer, Maja Mockenhaupt, Alexander Nast   +36 more
wiley   +1 more source

Triggers, clinical manifestations and assessment of paediatric fixed drug eruptions: A systematic review of the literature

Contact Dermatitis, Volume 90, Issue 4, Page 343-349, April 2024.
In this systematic review of the literature including 233 cases of paediatric FDE, we found that it is a non‐severe cutaneous drug reaction in the paediatric population, mainly caused by antibiotics. Younger patients presented with more extensive disease and mucosal involvement.
Audrey Mathieu, Mathilde de Grandmont, Carolina Lucena Fernandes, Elio Kechichian   +3 more
wiley   +1 more source

Hypersensitivity reactions to proton pump inhibitors. An EAACI position paper

Allergy, Volume 79, Issue 3, Page 552-564, March 2024.
Abstract Proton pump inhibitors (PPIs) are invaluable therapeutic options in a variety of dyspeptic diseases. In addition to their well‐known risk profile, PPI consumption is related to food and environmental allergies, dysbiosis, osteoporosis, as well as immediate and delayed hypersensitivity reactions (HSRs). The latter, although a rare event, around
Sevim Bavbek, Seçil Kepil Özdemir, Patrizia Bonadonna, Marina Atanaskovic‐Markovic, Annick Barbaud, Knut Brockow, Jose Laguna Martinez, Alla Nakonechna, Mauro Pagani, Alessandra Arcolacı, Carla Lombardo, Maria J. Torres   +11 more
wiley   +1 more source

Tadalafil-Induced Generalized Bullous Fixed Drug Eruption: A Rare Side Effect of a Common Drug. [PDF]

Cureus, 2023
Sarawgi D, Rudra O.
europepmc   +1 more source

Generalized Bullous Fixed Drug Eruption due to Clopidogrel Hypersensitivity Successfully Treated Using the Jefferson Procedure. [PDF]

J Cutan Pathol
Gillespie J, Jiang AJ, Fett N, Shea M, Keller JJ, Daryani S.   +5 more
europepmc   +1 more source