Results 161 to 170 of about 5,783,771 (297)

Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging.
Giammarco Milella   +5 more
wiley   +1 more source

Boundary‐Dependent Sleep–Wake Dysregulation in Idiopathic Hypersomnia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Idiopathic hypersomnia (IH) presents with excessive daytime sleepiness (EDS) despite apparently preserved nocturnal sleep, challenging traditional models of hypersomnolence based on sleep loss or fragmentation. We aimed to test the hypothesis that EDS in IH reflects excessive stabilization of the sleep state, consistent with ...
Samantha Mombelli   +13 more
wiley   +1 more source

Utility of the APE2 Score as a Diagnostic Tool for Autoimmune Encephalitis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To retrospectively evaluate the diagnostic performance of the Antibody Prevalence in Epilepsy and Encephalopathy (APE2) score relative to clinician‐adjudicated autoimmune encephalitis (AE) and the Graus criteria in a tertiary neuroimmunology referral cohort, including antibody‐negative AE.
Bijoya Basu   +3 more
wiley   +1 more source

Generalized Cross-Validation for Large Scale Problems

open access: yes, 1995
. Although generalized cross-validation is a popular tool for calculating a regularization parameter it has been rarely applied to large scale problems until recently.
Urs von Matt   +3 more
core  

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai   +13 more
wiley   +1 more source

Development and assessment of an artificial intelligence-based tool for scoring lesion severity in generalized pustular psoriasis clinical images. [PDF]

open access: yesJID Innov
Sabater A   +13 more
europepmc   +1 more source

Generalized Cross-Validation for Large Scale Problems

open access: yes, 1996
Although generalized cross-validation is a popular tool for calculating a regularization parameter it has been rarely applied to large scale problems until recently.
Urs von Matt, Gene H. Golub
core  

Early Clinical and Cerebrospinal Fluid Predictors of 1‐Year Recurrence in Autoimmune GFAP Astrocytopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) is an inflammatory central nervous system disorder with variable outcomes. Relapse occurs in a subset of patients, but early predictors remain unclear. We aimed to identify admission‐available features associated with 1‐year recurrence and develop an interpretable ...
Qingting Hong   +10 more
wiley   +1 more source

PERFORMANCE COMPARISON OF CROSS-VALIDATION TECHNIQUES IN FITTING GENERALIZED EXTREME VALUE (GEV) MODELS TO MONTHLY LOW-FLOW EXTREMES

open access: yesRevista de Gestão de Água da América Latina
This study compares the performance of the K-Fold (K=10) and Leave-One-Out (LOOCV) cross-validation techniques in assessing the goodness-of-fit of Extreme Value Distributions (EVDs) for low-flow hydrological extremes.
LUIZ ANTONIO DE OLIVEIRA
doaj  

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