Results 221 to 230 of about 492,581 (337)

Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD

Advanced Science, EarlyView.
Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du, Yinming Li, Rong Wu, Yufei Shen, Jiayi Yang, Xuan Xiao, Yu Zhou   +6 more
wiley   +1 more source

Machine Learning Models for Pancreatic Cancer Survival Prediction: A Multi-Model Analysis Across Stages and Treatments Using the Surveillance, Epidemiology, and End Results (SEER) Database. [PDF]

J Clin Med
Chakraborty A, Pant MD.
europepmc   +1 more source

Power series cure rate model for spatially correlated interval-censored data based on generalized extreme value distribution

, 2019
Bao Yiqi, Vicente G. Cancho, Dipak K. Dey, N. Balakrishnan, Adriano K. Suzuki   +4 more
openalex   +1 more source

Chloroplast Stress Signals Orchestrate Epidermis‐Specific Remodeling of Mitochondria and ER Under High Light

Advanced Science, EarlyView.
High light exposure triggers an epidermis‐specific remodeling of mitochondria and ER in Arabidopsis, driven by chloroplast‐derived signals. Live‐cell imaging shows that HL rapidly suppresses mitochondrial motility, followed by fusion‐driven elongation and ER cisternal expansion.
Evan R. Angelos, Hee‐Seung Choi, Jingzhe Guo, Andrea A. Zanini, Tessa M. Burch‐Smith, Emily Snyder, Matthew Part, Wilhelmina van de Ven, Manhoi Hur, Gerd Ulrich Balcke, Alain Tissier, Quanqing Zhang, Katayoon Dehesh   +12 more
wiley   +1 more source

Extreme flood return levels in a U.S. mid-Atlantic estuary using 40-year fluvial-coastal model simulations. [PDF]

Sci Data
Deb M, Sun N, Yang Z, Wang T, Judi D, Cooper MG, Wigmosta MS.   +6 more
europepmc   +1 more source

Assessment of alternative methods for analysing maximum rainfall spatial data based on generalized extreme value distribution [PDF]

Thales Rangel Ferreira, Gilberto Rodrigues Liska, Luiz Alberto Beijo   +2 more
openalex   +1 more source

A Closed‐Loop Hybrid Discovery System of Type I Photosensitizers for Hypoxic Tumor Therapy

Advanced Science, EarlyView.
The work developed a closed‐loop hybrid discovery system to rationally design and predict high‐performance Type I PSs for hypoxic tumor therapy. 664 Potential candidates are identified from a dataset through a support vector machine (SVM) classification model, and two candidates are experimentally verified as Type I PSs, which highlighted the potential
Xia Ling, Yixin Zhu, Min Li, Zongliang Xie, Lei Cao, Wentao Song, Dandan Wang, Duo Mao, Xiaonan Wang, Bin Liu   +9 more
wiley   +1 more source

A systematic approach to modeling monthly maximum temperature and total rainfall in Kenya. [PDF]

Sci Rep
Otieno K, Chaba L, Odhiambo C, Omolo B.
europepmc   +1 more source

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging‐Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases

Advanced Science, EarlyView.
This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen, Xin Wang, Haifeng Ding, Bosheng Zheng, Keni Zeng, Chuying Hu, Jiayi Liu, Xiao Zhu, Haibing Yu   +8 more
wiley   +1 more source

Chlamydia and gonorrhea incidence and residential segregation: US spatiotemporal patterns (2013-2021). [PDF]

BMC Public Health
Lessani MN, N'Diaye A, Li Z, Li X, Qiao S.   +4 more
europepmc   +1 more source