Results 51 to 60 of about 1,368 (262)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Weighted Hermite-Hadamard inequalities for r-times differentiable preinvex functions for k-fractional integrals

Demonstratio Mathematica, 2023
In this article, we have established some new bounds of Fejér-type Hermite-Hadamard inequality for kk-fractional integrals involving rr-times differentiable preinvex functions.
Zafar Fiza, Mehmood Sikander, Asiri Asim
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Generalized fractal Jensen and Jensen–Mercer inequalities for harmonic convex function with applications

Journal of Inequalities and Applications, 2022
In this paper, we present a generalized Jensen-type inequality for generalized harmonically convex function on the fractal sets, and a generalized Jensen–Mercer inequality involving local fractional integrals is obtained.
Saad Ihsan Butt, Praveen Agarwal, Saba Yousaf, Juan L. G. Guirao   +3 more
doaj   +1 more source

On a Generalized Laguerre Operational Matrix of Fractional Integration [PDF]

Mathematical Problems in Engineering, 2013
A new operational matrix of fractional integration of arbitrary order for generalized Laguerre polynomials is derived. The fractional integration is described in the Riemann-Liouville sense. This operational matrix is applied together with generalized Laguerre tau method for solving general linear multiterm fractional differential equations (FDEs). The
Bhrawy, A. H., Baleanu, Dumitru, Assas, L. M., Machado, J.A.Tenreiro   +3 more
openaire   +3 more sources

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

New version of midpoint-type inequalities for co-ordinated convex functions via generalized conformable integrals

Boundary Value Problems
In the current research, some midpoint-type inequalities are generalized for co-ordinated convex functions with the help of generalized conformable fractional integrals.
Mehmet Eyüp Kiriş, Miguel Vivas-Cortez, Tuğba Yalçin Uzun, Gözde Bayrak, Hüseyin Budak   +4 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Fractional Integral Inequalities concerning Extended Bessel Function in the Kernel

Journal of Mathematics, 2021
The major purpose of this paper is to use the fractional integral operator in terms of extended generalized Bessel function to estimate new fractional integral inequalities for the extended Chebyshev functional in the sense of synchronous functions.
Arshad Hussain, Gauhar Rahman, Jihad Younis, Muhammad Samraiz, Muhammad Iqbal   +4 more
doaj   +1 more source