Results 81 to 90 of about 1,368 (262)

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie, Xiaotong Li, Venkata Sita Priyanka Illapani, Leigh N. Sepeta, Jason Schroeder, Chima O. Oluigbo, Madison M. Berl, William D. Gaillard, Nathan T. Cohen   +8 more
wiley   +1 more source

Fractional Calculus of Variations in Terms of a Generalized Fractional Integral with Applications to Physics

Abstract and Applied Analysis, 2012
We study fractional variational problems in terms of a generalized fractional integral with Lagrangians depending on classical derivatives, generalized fractional integrals and derivatives.
Tatiana Odzijewicz, Agnieszka B. Malinowska, Delfim F. M. Torres   +2 more
doaj   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

Existence and Stability Results for Differential Equations with a Variable-Order Generalized Proportional Caputo Fractional Derivative

Mathematics
An initial value problem for a scalar nonlinear differential equation with a variable order for the generalized proportional Caputo fractional derivative is studied. We consider the case of a piecewise constant variable order of the fractional derivative.
Donal O’Regan, Ravi P. Agarwal, Snezhana Hristova, Mohamed I. Abbas   +3 more
doaj   +1 more source

On the boundedness of a generalized fractional integral on generalized Morrey spaces

Tamkang Journal of Mathematics, 2002
In this paper we extend Nakai's result on the boundedness of a generalized fractional integral operator from a generalized Morrey space to another generalized Morrey or Campanato space.
openaire   +4 more sources

An introduction to the generalized fractional integration

Boletim da Sociedade Paranaense de Matemática, 2012
Summary: The purpose of the present paper is to investigate the generalized fractional integration of the generalized \(M\)-series. Some results derived by \textit{R. K. Saxena} and \textit{M. Saigo} [Fract. Calc. Appl. Anal. 8, No. 2, 141--154 (2005; Zbl 1144.26010)], \textit{St. G. Samko} et al.
openaire   +2 more sources

Some generalized integral inequalities via fractional integrals

, 2020
Summary: The main goal of this paper is to introduce a new integral definition concerned with the fractional calculus. Then we establish generalized Hermite-Hadamard type integral inequalities for convex functions using the proposed fractional integrals. The results presented provide extensions of those given in earlier works.
Sarıkaya, Mehmet Zeki, Budak, Hüseyin, Usta, Fuat   +2 more
openaire   +3 more sources