Improved estimation of functional enrichment in SNP heritability using feasible generalized least squares [PDF]
Summary: Functional enrichment results typically implicate tissue or cell-type-specific biological pathways in disease pathogenesis and as therapeutic targets.
Zewei Xiong +3 more
doaj +2 more sources
Understanding Peelle’s Pertinent Puzzle bias in generalized least squares regression through eigenspectrum analysis [PDF]
Certain correlation structures in the data covariance matrix (DCM) used for generalized least squares (GLS) regression can result in biased estimates, commonly known in the field of nuclear data evaluation as Peele’s Pertinent Puzzle (PPP).
Noah A. W. Walton +5 more
doaj +2 more sources
A generalized least-squares framework for rare-variant analysis in family data. [PDF]
Rare variants may, in part, explain some of the hereditability missing in current genome-wide association studies. Many gene-based rare-variant analysis approaches proposed in recent years are aimed at population-based samples, although analysis ...
Li D, Rotter JI, Guo X.
europepmc +3 more sources
GEEQBOX: A MATLAB Toolbox for Generalized Estimating Equations and Quasi-Least Squares [PDF]
The GEEQBOX toolbox analyzes correlated data via the method of generalized estimating equations (GEE) and quasi-least squares (QLS), an approach based on GEE that overcomes some limitations of GEE that have been noted in the literature.
Sarah J. Ratcliffe, Justine Shults
doaj +1 more source
Kernel generalized least squares regression for network-structured data [PDF]
Edward Antonian +2 more
doaj +2 more sources
New Developments in Sparse PLS Regression
Methods based on partial least squares (PLS) regression, which has recently gained much attention in the analysis of high-dimensional genomic datasets, have been developed since the early 2000s for performing variable selection.
Jérémy Magnanensi +6 more
doaj +1 more source
Markdown Optimization with Generalized Weighted Least Squares Estimation
Retailers increasingly apply price markdowns for their seasonal products. Efficiency of these markdown applications is driven by the accuracy of empirical models, especially toward the end of a selling season.
Mustafa Hekimoğlu
doaj +1 more source
Factor Analysis by Generalized Least Squares [PDF]
Aitken’s generalized least squares (GLS) principle, with the inverse of the observed variance-covariance matrix as a weight matrix, is applied to estimate the factor analysis model in the exploratory (unrestricted) case. It is shown that the GLS estimates are scale free and asymptotically efficient.
Jöreskog, Karl G. +1 more
openaire +2 more sources
A Generalized Variable Projection Algorithm for Least Squares Problems in Atmospheric Remote Sensing
This paper presents a solution for efficiently and accurately solving separable least squares problems with multiple datasets. These problems involve determining linear parameters that are specific to each dataset while ensuring that the nonlinear ...
Adelina Bärligea +2 more
doaj +1 more source
Regression procedures are often used for estimating distributional parameters because of their computational simplicity and useful graphical presentation. However, the resulting regression model may have heteroscedasticity and/or correction problems and
Yeliz Mert Kantar
doaj +1 more source

