Results 221 to 230 of about 575,678 (274)
Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice
Advanced Healthcare Materials, EarlyView.A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec +5 more
wiley +1 more source
Shellac‐Mediated Assembly of Nanoparticles for mRNA Delivery
Advanced Healthcare Materials, EarlyView.A shellac‐mediated nanoparticle assembly strategy is presented, involving the complexation of mRNA and low‐molecular‐weight cationic molecules (e.g., polyethyleneimine, chitosan, lipids, and poly‐l‐lysine), followed by capping with shellac. This nanoparticle platform enables mRNA transfection following intravenous injection and facilitates gene editing
Meizhang Lu +7 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.A superhydrophobic 3D cell culture platform enables rapid and consistent formation of heterotypic tumor–stroma clusters, and reveals how physiological shear conditions influence metastatic signaling. Mechanical stimulation of cancer‐associated fibroblasts promotes sustained cytokine secretion and survival‐promoting pathways, showing how multicellular ...
Alexandria T. Carter +5 more
wiley +1 more source
Joint Modeling of Longitudinal and Survival Data in Public Health and Biomedical Research: A Systematic Review. [PDF]
Int J Environ Res Public HealthWang W, Bursac Z, Hu N.
europepmc +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Linear Equality Constraints in the General Linear Mixed Model
Biometrics, 2001Scientists may wish to analyze correlated outcome data with constraints among the responses. For example, piecewise linear regression in a longitudinal data analysis can require use of a general linear mixed model combined with linear parameter constraints.
Edwards, Lloyd J. +3 more
openaire +3 more sources
Model comparison of generalized linear mixed models
Statistics in Medicine, 2005AbstractGeneralized linear mixed models (GLMMs) have been widely appreciated in biological and medical research. Maximum likelihood estimation has received a great deal of attention. Comparatively, not much has been done on model comparison or hypotheses testing.
Xin-Yuan, Song, Sik-Yum, Lee
openaire +2 more sources
Linear and Generalized Linear Mixed Models and Their Applications
Technometrics, 2008(2008). Linear and Generalized Linear Mixed Models and Their Applications. Technometrics: Vol. 50, No. 1, pp. 93-94.
openaire +1 more source
Generalized linear mixed models for meta-analysis
Statistics in Medicine, 1999We examine two strategies for meta-analysis of a series of 2 x 2 tables with the odds ratio modelled as a linear combination of study level covariates and random effects representing between-study variation. Penalized quasi-likelihood (PQL), an approximate inference technique for generalized linear mixed models, and a linear model fitted by weighted ...
R W, Platt, B G, Leroux, N, Breslow
openaire +2 more sources
Generalized quasi-linear mixed-effects model
Statistical Methods in Medical Research, 2022The generalized linear mixed model (GLMM) is one of the most common method in the analysis of longitudinal and clustered data in biological sciences. However, issues of model complexity and misspecification can occur when applying the GLMM. To address these issues, we extend the standard GLMM to a nonlinear mixed-effects model based on quasi-linear ...
Yusuke Saigusa +2 more
openaire +2 more sources