Results 41 to 50 of about 134,460 (206)

Analysis of Fluid Velocity inside an Agricultural Sprayer Using Generalized Linear Mixed Models

Applied Sciences, 2020
The fluid velocity inside the tank of agricultural sprayers is an indicator of the quality of the mixture. This study aims to formulate the best generalized linear mixed model to infer the fluid velocity inside a tank under specific operational ...
Ángel Javier Aguirre, Guillermo E. Guevara-Viera, Carlos S. Torres-Inga, Raúl V. Guevara-Viera, Antonio Boné, Mariano Vidal, Francisco Javier García-Ramos   +6 more
doaj   +1 more source

Spatial variability in floodplain sedimentation: the use of generalized linear mixed-effects models [PDF]

Hydrology and Earth System Sciences, 2010
Sediment, Total Organic Carbon (TOC) and total nitrogen (TN) accumulation during one overbank flood (1.15 y return interval) were examined at one reach of the Middle Ebro River (NE Spain) for elucidating spatial patterns. To achieve this goal, four areas
A. Cabezas, M. Angulo-Martínez, M. Gonzalez-Sanchís, J. J. Jimenez, F. A. Comín   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A reproducible, diagnostic-guided hybrid Laplace workflow for generalized linear mixed models

MethodsX
Laplace approximation is widely used for generalized linear mixed models because it is fast and compatible with automatic-differentiation software, yet its accuracy can deteriorate when clusters are weakly informative, outcomes are sparse, or conditional
Mohammad M. Hamasha
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Effect of imperfect detection on the estimation of niche overlap between two forest dormice

iForest - Biogeosciences and Forestry, 2018
Quantification of niche overlap represents an important topic in several aspects of ecology and conservation biology, although it could be potentially affected by imperfect detection, i.e., failure to detect a species at occupied sites.
Paniccia C, Di Febbraro M, Frate L, Sallustio L, Santopuoli G, Altea T, Posillico M, Marchetti M, Loy A   +8 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Analysis of neonatal clinical trials with twin births

BMC Medical Research Methodology, 2009
Background In neonatal trials of pre-term or low-birth-weight infants, twins may represent 10–20% of the study sample. Mixed-effects models and generalized estimating equations are common approaches for handling correlated continuous or binary data ...
Shaffer Michele L, Kunselman Allen R, Watterberg Kristi L   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source