Results 71 to 80 of about 575,678 (274)
BMC Bioinformatics, 2020 Background Power analysis becomes an inevitable step in experimental design of current biomedical research. Complex designs allowing diverse correlation structures are commonly used in RNA-Seq experiments.
Lianbo Yu, Soledad Fernandez, Guy Brock
doaj +1 more source
Spatial variability in floodplain sedimentation: the use of generalized linear mixed-effects models [PDF]
Hydrology and Earth System Sciences, 2010 Sediment, Total Organic Carbon (TOC) and total nitrogen (TN) accumulation during one overbank flood (1.15 y return interval) were examined at one reach of the Middle Ebro River (NE Spain) for elucidating spatial patterns. To achieve this goal, four areas
A. Cabezas +4 more
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Global and local distance-based generalized linear models [PDF]
, 2016 This paper introduces local distance-based generalized linear models. These models extend (weighted) distance-based linear models first to the generalized linear model framework. Then, a nonparametric version of these models is proposed by means of local
Boj, Eva +4 more
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Testing for misspecification in generalized linear mixed models [PDF]
Biostatistics, 2010 Generalized linear mixed models have become a frequently used tool for the analysis of non-Gaussian longitudinal data. Estimation is often based on maximum likelihood theory, which assumes that the underlying probability model is correctly specified.
Alonso Abad, Ariel +2 more
openaire +4 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa +8 more
wiley +1 more source
The subset argument and consistency of MLE in GLMM: Answer to an open problem and beyond [PDF]
, 2013 We give answer to an open problem regarding consistency of the maximum likelihood estimators (MLEs) in generalized linear mixed models (GLMMs) involving crossed random effects.
Jiang, Jiming
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source