Results 181 to 190 of about 72,305 (216)

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Preoperative frailty and tumor volume as determinants of primary management strategy and outcomes in petroclival meningioma patients. [PDF]

Front Surg
Kashlan R, Faraj R, Duggireddy H, Zohdy YM, Hasa A, Agudelo Arrieta M, Barrero Ruiz E, Assi J, Rodas A, Salmeron-Moreno K, Maldonado J, Tariciotti L, Pradilla G, Garzon-Muvdi T.   +13 more
europepmc   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Predictors of childhood vaccination and recent influenza vaccination in older Brazilian adults: an analysis using conventional regression and machine learning approaches. [PDF]

Front Public Health
Xu X, Wang B, Memon KM, Sun C, Cheng Y, Long F.   +5 more
europepmc   +1 more source

Robots and Minimal, Physics‐Informed Features: A Hybrid Framework for Enzyme Catalysis

Advanced Science, EarlyView.
Robotic experimentation and physics‐informed machine learning combine to predict enzyme substrate scope. With a handful of interpretable features derived from docking and quantum mechanics calculations, our model rivals descriptor‐heavy AI approaches and extrapolates to unseen substrates and enzyme classes.
Natalia Onishchenko, Eric S. Larsen, Govind Paneru, Kisung Lee, Diana V. Kolygina, Yankai Jia, Elizabeth Maria Clarissa, Wai‐Shing Wong, Bartosz A. Grzybowski   +8 more
wiley   +1 more source

Factors Influencing Operational Delays in Prehospital Trauma Interventions: Evidence from a Romanian Cohort. [PDF]

Medicina (Kaunas)
Haută A, Iacobescu RA, Nedelea PL, Corlade-Andrei M, Blaga T, Ivanuta M, Ivanuta A, Cimpoeșu CD.   +7 more
europepmc   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Association of lipoprotein indices with 3-month functional outcome after ischemic stroke: a retrospective cohort study. [PDF]

Front Nutr
Rao Z, Xu C, Yu Y, Zhu G, Liu Y, Wen X, Zhu C, Zhang Y.   +7 more
europepmc   +1 more source